FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Label-free metabolic fingerprinting of motile mammalian spermatozoa with subcellular resolution
BMC BiologyBackground Sperm metabolic pathways that generate energy for motility are compartmentalized within the flagellum. Dysfunctions in metabolic compartments, namely mitochondrial respiration and glycolysis, can compromise motility and male fertility ...
Fitore Kusari +4 more
doaj +1 more source
Identification of a putative germ plasm in the amphipod Parhyale hawaiensis [PDF]
, 2014 Background: Specification of the germ line is an essential event during the embryonic development of sexually reproducing animals, as germ line cells are uniquely capable of giving rise to the next generation.
Extavour, Cassandra G, Gupta, Tripti
core +1 more source
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration. [PDF]
, 2020 Gas1 and Boc/Cdon act as co-receptors in the vertebrate Hedgehog signalling pathway, but the nature of their interaction with the primary Ptch1/2 receptors remains unclear.
A Kolpak +57 more
core +3 more sources
A role for Lin28 in primordial germ-cell development and germ-cell malignancy [PDF]
Nature, 2009 The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwart efforts to investigate molecular mechanisms of germ-cell specification. stella (also called Dppa3) marks the rare founder population of the germ lineage.
In-Hyun Park +12 more
openaire +3 more sources
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
In vitro germ cell differentiation from cynomolgus monkey embryonic stem cells. [PDF]
PLoS ONE, 2009 BACKGROUND: Mouse embryonic stem (ES) cells can differentiate into female and male germ cells in vitro. Primate ES cells can also differentiate into immature germ cells in vitro.
Kaori Yamauchi +4 more
doaj +1 more source
Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHT [PDF]
, 1997 Drosophila embryos lacking hindsight gene function have a normal body plan and undergo normal germ-band extension. However, they fail to retract their germ bands.
Lamka, Michele L. +2 more
core
Germinal Epithelium Cytology during Spermatogenesis in the Alligator Snapping Turtle, Macrochelys temminckii (Reptilia: Chelydridae) [PDF]
, 2018 We investigated the cytology of the seminiferous epithelia of the Alligator Snapping Turtle (Macrochelys temminckii). Spermatogenic and regressed testes were assessed from 2 adult individuals collected in Arkansas in May and September of 1993 ...
Gribbins, Kevin M., Trauth, Stanley E.
core +3 more sources
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source