Results 41 to 50 of about 11,236 (211)

The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer [PDF]

, 2014
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance ...
Barry-O'Crowley, Jacqui, Bates, Mark, Cooke, Aoife A., Costello, Katie M., D'Arcy, Tom, D’Adhemar, Charles J., Ffrench, Brendan, Finn, Stephen, Flood, Brian, Gallagher, Michael F., Gleeson, Noreen, Haley, Kathryn, Hennessy, Bryan T., Kernan, Niamh, Martin, Cara M., McCann, Amanda, Murphy, Ciara, O'Byrne, Ken, O'Donnell, Dearbhaile, O'Leary, John J., O'Neill, Luke A. J., O'Toole, Sharon, Pennington, Stephen, Sheils, Orla, Smyth, Paul C., Spillane, Cathy D., Stordal, Britta K.   +26 more
core   +3 more sources

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Advances in the study of tumor markers for intracranial germ cell tumors

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Intracranial germ cell tumors (ICGCTs) are highly heterogeneous tumors that tend to occur in children and adolescents, and their diagnosis and treatment strategies are closely related to their pathological components.
Lei HAN, Zi⁃jun HE, Lu⁃xiong FANG, Ye SONG   +3 more
doaj  

Testis-sparing surgery for benign and malignant tumors: A critical analysis of the literature

Indian Journal of Urology, 2008
In order to explore the latest advances in organ-sparing treatment of testicular tumors, a literature search of the Medline/PubMed database was carried out for published data in the English language up to 2007.
Gianluca Giannarini, Andrea Mogorovich, Irene Bardelli, Francesca Manassero, Cesare Selli   +4 more
doaj   +1 more source

A multi-disciplinary Delphi method to identify consensus in the management of intracranial germ cell tumours [PDF]

, 2015
The management of intracranial germ-cell tumours is complex because of varied clinical presentations, tumour sites, treatments and outcomes, and the need for multidisciplinary input.
Bartels, Ute, Fangusaro, Jason, Matsutani, Masao, Murray, Matthew J, Nicholson, James C, Nishikawa, Ryo   +5 more
core   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Cell Germ primary tumor of mediastinum (seminoma of mediastinum)

Archivo Médico de Camagüey, 2019
Background: the anterior mediastinal germ cell tumor is a formation of neoplastic cells located in the mediastinum. They are formed by congenital defects in the embryonic stage by migration of the primordial germ cell and dermal cells that are within the
René Hernández-Benedicto, Rafael Pila-Pérez, Pedro Rosales-Torres   +2 more
doaj  

An Unusual Case of Primary Retroperitoneal Germ Cell Tumour in a Young Man

European Journal of Case Reports in Internal Medicine, 2018
Some 2–5% of germ cell tumours are of extragonadal origin, with a retroperitoneal location being very rare. The majority of retroperitoneal germ cell tumours have metastasized from a testicular tumour.
Maria João Raposo Linhares Serpa, Susana Franco, Diana Repolho, Francisco Branco, João Gramaça, José Ferreira Júnior   +5 more
doaj   +1 more source

Mapping of succinate dehydrogenase losses in 2258 epithelial neoplasms. [PDF]

, 2014
Losses in the succinate dehydrogenase (SDH) complex characterize 20% to 30% of extra-adrenal paragangliomas and 7% to 8% of gastric GISTs, and rare renal cell carcinomas.
Biernat, Wojciech, Czapiewski, Piotr, Langfort, Renata, Lasota, Jerzy, McCue, Peter, Miettinen, Markku, Sarlomo-Rikala, Maarit, Waloszczyk, Piotr, Wang, Zengfeng, Wazny, Krzysztof   +9 more
core   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source