Results 121 to 130 of about 10,882,992 (336)

Insights into female germ cell biology: from in vivo development to in vitro derivations

Asian Journal of Andrology, 2015
Understanding the mechanisms of human germ cell biology is important for developing infertility treatments. However, little is known about the mechanisms that regulate human gametogenesis due to the difficulties in collecting samples, especially germ ...
Dajung Jung, Kehkooi Kee
doaj   +1 more source

Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions. [PDF]

, 2015
BackgroundCTCF and BORIS (CTCFL), two paralogous mammalian proteins sharing nearly identical DNA binding domains, are thought to function in a mutually exclusive manner in DNA binding and transcriptional regulation.ResultsHere we show that these two ...
Boukaba, Abdelhalim, Espinoza, Celso A, Kang, Sungyun, Kosaka-Suzuki, Natsuki, Lobanenkov, Victor V, Loukinov, Dmitri, Méndez-Catalá, Claudia Fabiola, Nagarajan, Vijayaraj, Pugacheva, Elena M, Rasko, John EJ, Ren, Bing, Rivero-Hinojosa, Samuel, Robinson, Susan, Strunnikov, Alexander V, Suzuki, Teruhiko, Ye, Zhen   +15 more
core   +3 more sources

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Immature germ cells in semen - correlation with total sperm count and sperm motility

Journal of Cytology, 2013
Background: Current data regarding infertility suggests that male factor contributes up to 30% of the total cases of infertility. Semen analysis reveals the presence of spermatozoa as well as a number of non-sperm cells, presently being mentioned in ...
Priya S Patil, Rajendra S Humbarwadi, Ashalata D Patil, Anita R Gune   +3 more
doaj   +1 more source

Transcription of nanos-1 in Zebrafish Embryos is not Affected by Bisphenol A: Evaluated Using Quantitative Real-Time PCR [PDF]

, 2019
The presence of primordial germ cells (PGCs) is crucial for proper gonad formation in zebrafish (Danio rerio). The many aspects of PGC migration that allow these cells to reach the proper location at the gonadal ridge include receptors, ligands, germ ...
Babich, Bridget, Callahan, Kevin, Freeman, Edward A., Roba, George, Safura, Siti Sarah   +4 more
core   +1 more source

Basic fibroblast growth factor (bFGF) in rodent testis [PDF]

, 1992
We have previously described a 30 kDa basic fibroblast growth factor (bFGF)-like protein in rodent testicular homogenates and have shown that pachytene spermatocytes are the sites of predominant immunoreactivity for this bFGF-like protein (Mayerhofer, A.,
Artur Mayerhofer, Barthels, Beilvé, Bellvé, Braunhut, Claudia Grothe, Djakiew, Facett, Georgia Lahr, Gospodarowicz, Grothe, Grothe, Jaillard, Kaplan, Kimmelman, Klaus Seidl, Kurokawa, Lahr, Maier, Manfred Gratzl, Mayerhofer, Moscatello, Prats, Presta, Sabine Bucher, Sharpe, Skinner, Smith, Storey, Ueno, Volk, Walter Knöchel, Westermann, Wolgemuth   +33 more
core   +1 more source

Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development

Advanced Science, EarlyView.
Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen, Jian‐Rong Yang   +14 more
wiley   +1 more source

RNA granules in germ cells.

Cold Spring Harbor Perspectives in Biology, 2011
"Germ granules" are cytoplasmic, nonmembrane-bound organelles unique to germline. Germ granules share components with the P bodies and stress granules of somatic cells, but also contain proteins and RNAs uniquely required for germ cell development.
Ekaterina Voronina, G. Seydoux, P. Sassone-Corsi, I. Nagamori   +3 more
semanticscholar   +1 more source

In vitro responses to known in vivo genotoxic agents in mouse germ cells [PDF]

, 2017
YesGenotoxic compounds have induced DNA damage in male germ cells and have been associated with adverse clinical outcomes including enhanced risks for maternal, paternal and offspring health.
Anderson, Diana, Brinkworth, Martin H., Habas, Khaled S.A.   +2 more
core   +1 more source

The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots

Advanced Science, EarlyView.
DNA is thought to determine shape, behavior, and lifespan, with developmental plasticity reserved for stem cells, embryos, and species like amphibia. How much morphogenetic plasticity do adult somatic human cells exhibit? Anthrobots are a self‐organizing, motile synthetic living construct made of genetically normal human epithelial cells.
Gizem Gumuskaya, Nikolai Davey, Pranjal Srivastava, Andrew Bender, Léo Pio‐Lopez, Douglas Hazel, Michael Levin   +6 more
wiley   +1 more source