Animal Models and Experimental Medicine, EarlyView.Multiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Ivan Koprivica +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.Understanding the mode of action is critical to develop new antifungal drugs. Solid‐state NMR was used to study the reorganization of the Aspergillus fumigatus cell wall by a host‐defence peptide. We identified specific polysaccharides and amino acids that are affected by the peptide.
Ajit Kumar Bishoyi +5 more
wiley +2 more sources
Development of an efficient mice model of cancer‐associated cardiac cachexia
Animal Models and Experimental Medicine, EarlyView.This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong +9 more
wiley +1 more source
Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells. [PDF]
ElifeAlexander AK +7 more
europepmc +1 more source
Engineered Hydrogels Revolutionize Locoregional Cancer Immunotherapy
Advanced NanoBiomed Research, EarlyView.This review systematically summarizes the latest research progress on injectable hydrogels in cancer immunotherapy, highlighting their unique advantages in precise immune activation, local drug‐controlled release, and immune microenvironment remodeling. These features provide innovative solutions to overcome the bottlenecks of systemic side effects and
Jiyong Wei +3 more
wiley +1 more source
A positive feedback loop between germ cells and gonads induces and maintains sexual reproduction in a cnidarian. [PDF]
Sci AdvCurantz C +6 more
europepmc +1 more source
Nanostructured Biomaterial‐Based Approaches to Support Induced Pluripotent Stem Cell Differentiation
Advanced NanoBiomed Research, EarlyView.Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, represent an innovative approach for regenerative medicine and biomedical applications. This review highlights the importance of nanostructured biomaterials, utilized as delivery systems or scaffolds, in supporting iPSC differentiation and fate through structural and ...
Beatriz A. B. R. Passos +2 more
wiley +1 more source
PM2.5 from automobile exhaust induces apoptosis in male rat germ cells via the ROS-UPRmt signaling pathway. [PDF]
PLoS OneWang C +5 more
europepmc +1 more source
Achieving Optimal Transfection Conditions in Chicken Primordial Germ Cells Under Feeder- and Serum-Free Medium. [PDF]
Animals (Basel)Zhao Z +8 more
europepmc +1 more source
Autoradiographic Evidence of Human Male Germ-cell Differentiation <i>in vitro</i>
, 1971 R Matte, Motomichi Sasaki
openalex +2 more sources