Results 101 to 110 of about 3,966,612 (344)

Meaning in life in the Federal Republic of Germany: results of a representative survey with the Schedule for Meaning in Life Evaluation (SMiLE) [PDF]

, 2007
Martin Fegg, Mechtild Kramer, Claudia Bausewein, Gian Domenico Borasio   +3 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Blood group determinates incidence for pancreatic cancer in Germany [PDF]

, 2013
Uwe Pelzer, F. Klein, M. Bahra, M. Sinn, Bernd Dörken, P. Neuhaus, Oliver Meyer, Hanno Riess   +7 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Eine neue kontrastiv-typologische Analyse der Onomatopoetika im Deutschen und Rumänischen [PDF]

Diversitate si Identitate Culturala in Europa
A NEW CONTRASTIVE-TYPOLOGICAL ANALYSIS OF ONOMATOPOEIA IN GERMAN AND ROMANIAN The seemingly obvious assumption that onomatopoeia faithfully reproduces the sounds of society and that these sounds are the same for all speakers is invalidated by the ...
Ioana Hermine FIERBINȚEANU
doaj  

Higher self‐reported severity of atopic dermatitis in adults is associated with poorer self‐reported health‐related quality of life in France, Germany, the U.K. and the U.S.A. [PDF]

, 2019
Liv Øinæs Andersen, Martin Erik Nyeland, Fredrik Nyberg   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Request for confirmation sequences in German

Open Linguistics
In request for confirmation (RfC) sequences, interlocutors negotiate their social positions regarding access and rights to knowledge. The article presents an overview of a quantitative analysis of 200 RfCs and their responses in German conversations to ...
Deppermann Arnulf, Gubina Alexandra, König Katharina, Pfeiffer Martin   +3 more
doaj   +1 more source

Almanca Kökenli Sözcüklere Önerilen Karşılıklar: Derlem Dilbilim ve Yapay Zekâ Temelli Bir Araştırma

Turcology Research
Toplumlar arasında gerçekleşen ticari ilişkiler, bilim, sanayi ve teknolojideki ilerlemeler kültürlerarası etkileşimi artırmaktadır. Kültürlerarası etkileşim sonucunda diller arasında sözcük alış-verişi gerçekleşmektedir.
Harun Göçerler, Uğur Özgür
doaj   +1 more source