Results 101 to 110 of about 3,898,323 (346)

Opportunities to Develop Intercultural Communicative Competence in Czech lower-secondary schools: Findings of the IRSE Video Study of German

open access: yesJournal of Language and Cultural Education, 2018
The empirical study deals with the topic of teaching intercultural communicative competence (ICC) in Czech lower-secondary German classes. The aim of the study is to investigate the quantity and quality of the opportunities to develop ICC, the proportion
Zerzová Jana
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Training elements in football. Differences in the training system between polish club and german club

open access: yesQuality in Sport, 2015
In modern football control and monitoring of training can increase the effectiveness of teaching. It’s going to provide coaches and athletes comprehensive training conditions.
Paweł Kalinowski, Katarzyna Judreczka
doaj   +1 more source

The German situation [PDF]

open access: yesBritish Journal of Sports Medicine, 2000
Over the past century, education in sports medicine and exercise physiology in Germany has undergone various modifications. Furthermore, the reunification of the country over the last decade has caused political and economic changes resulting in fundamental and continuing changes in education and in the professions of general doctors, clinically ...
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Sprache als Erinnerungsort der Kultur: Die Bedeutung von Wortfeldern für das Sprachverständnis

open access: yesInterkulturelles Forum der deutsch-chinesischen Kommunikation
Dieser Artikel behandelt das Thema Kultur und Wortfelder. An Stelle der realen Welt stellt jede Sprache eine halb fiktive Version von Dingen dar. Sprache schafft ihre eigene Sicht auf die Welt. Dies führt zu unterschiedlichen Wortfeldern für jede Sprache.
Klatt Gunnar, Qi Dongdong
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

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