Results 151 to 160 of about 16,417,253 (231)

Genomic Features Do Not Account for Differences in Multiple Myeloma Risk by Ancestry. [PDF]

Blood Cancer Discov
Maclachlan KH, Papadimitriou M, Blaney P, Baughn LB, Shekarkhand T, Poos AM, Ziccheddu B, Tang H, Yan H, Diamond B, Zhang Y, Cimera R, Dogan A, Gagler D, Boyle E, Hultcrantz M, Mailankody S, Hassoun H, Shah UA, Tan C, Brown EE, Winterkorn L, Chu T, Steinsnyder Z, Vaksman Z, Davies FE, Korde N, Landgren O, Raab MS, Lesokhin AM, Robine N, Weinhold N, Usmani SZ, Maura F, Morgan GJ.   +34 more
europepmc   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

In vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart. [PDF]

Nat Commun
Mintcheva J, Tseng TL, Goumenaki P, Neuschulz A, Senoussi A, Lelek S, Lim KL, Ming Z, Schäfer R, Hnatiuk A, Ninov N, Beisaw A, McGrail M, Lai SB, Panáková D, Stainier DYR, Junker JP.   +16 more
europepmc   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Interacting Species Database (ISDB): comprehensive resource for interspecies interactions at the molecular level. [PDF]

Bioinformatics
Mederer M, Gautam A, Kohlbacher O, Lupas A, Elhabashy H.   +4 more
europepmc   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Histone H3 Acetylation at <i>Sox1ot</i> Promoter by Targeted Epigenome Editing Augments Proliferation of Intermediate Progenitors in Developing Cortex. [PDF]

Biology (Basel)
Sokpor G, Ulmke PA, Nguyen HD, Pham L, Kakani P, Chu VT, Arnold SJ, Brand-Saberi B, Nguyen HP, Tuoc T.   +9 more
europepmc   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Genome-wide association studies of missing metabolite measures from two population-based studies. [PDF]

Genome Biol
Faquih TO, Imtiaz MA, Talevi V, Landstra EN, van Hylckama Vlieg A, Li-Gao R, Rosendaal FR, Noordam R, van Heemst D, Mook-Kanamori DO, Breteler MMB, Aziz NA, van Dijk KW.   +12 more
europepmc   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source