Results 151 to 160 of about 10,163 (200)

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Multimodal plasma and urinary cell-free DNA profiling improves risk stratification in newly diagnosed prostate cancer. [PDF]

NPJ Precis Oncol
Riediger AL, Eickelschulte S, Janke F, Janscho D, Lazareva O, Hübschmann D, Duensing S, Stegle O, Sültmann H, Görtz M.   +9 more
europepmc   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Clonally expanded effector CD4⁺ cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy. [PDF]

J Immunother Cancer
Giguelay AM, Maschmeyer P, Müller-Jensen L, Schinke C, Maierhof SK, Nambiar N, Meyer M, Huehnchen P, Boehmerle W, Endres M, Knauss S, Ludwig LS.   +11 more
europepmc   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Influence of social media channels on tobacco product consumption behaviors in people aged 18-30 years. [PDF]

Front Public Health
Hanke R, Hoheisel A, Yang KY, Kloß A, Cherrez-Ojeda I, Stolz D.   +5 more
europepmc   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Epigenome-wide association study of circulating interleukin-6 connects DNA methylation to immunometabolic and inflammatory health. [PDF]

Commun Biol
Sinke L, van Dongen J, Delerue T, Wilson R, Xia Y, Beekman M, Willemsen G, Gieger C, Herder C, Koenig W, Peters A, de Geus EJC, Ordovas JM, Bell JT, Waldenberger M, Boomsma DI, Slagboom PE, Heijmans BT.   +17 more
europepmc   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Molecular architecture of human dermal sleeping nociceptors. [PDF]

Cell
Körner J, Howard D, Solinski HJ, Mancilla Moreno M, Haag N, Fiebig A, Maxion A, Bhuiyan SA, Toklucu I, Bott RA, Sankaranarayanan I, Tavares-Ferreira D, Shiers S, Inturi NN, Eberhardt E, Ernst L, Bonaguro L, Schulte-Schrepping J, Beyer MD, Stiehl T, Renthal W, Kurth I, Tigerholm J, Serra J, Price TJ, Schmelz M, Namer B, Tripathy S, Lampert A.   +28 more
europepmc   +1 more source