Results 171 to 180 of about 10,163 (200)

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene editing for genetic hyperinflammation. [PDF]

Cell Stem Cell
Lei L, Kaufmann MM, Lao J, Thoulass G, Ammann S, Xiao H, Rhiel M, Dettmer-Monaco V, Grünewald J, Andrieux G, Alzubi J, Miller BR, Weißert K, Gräßel L, Schell C, Illert AL, Joung JK, Boerries M, Cornu TI, Ehl S, Erlacher M, Aichele P, Cathomen T.   +22 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Protocol of the LEONORA randomized clinical trial: Lower gastrointestinal symptom burden by prophylaxis with synbiotics after colorectal cancer surgery. [PDF]

BMC Cancer
Schöttker B, Kopp-Schneider A, Biehl L.
europepmc   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Respiratory syncytial viral load drives ciliated cell dedifferentiation and suppresses antiviral immunity. [PDF]

Sci Adv
Berg K, Haid S, Vafadarnejad E, Carpentier A, Geffers R, Wiegmann B, Saliba AE, Erhard F, Pietschmann T.   +8 more
europepmc   +1 more source

Daratumumab in systemic lupus erythematosus: a single-arm phase 2 trial. [PDF]

Nat Commun
Ostendorf L, Zernicke J, Klotsche J, Kempkens R, Beenken AE, Biesen R, Cheng Q, Khodadadi L, Guerra GM, Heinrich F, Durek P, Burmester GR, Krönke G, Hiepe F, Mashreghi MF, Alexander T.   +15 more
europepmc   +1 more source

Perioperative Antibiotic Prophylaxis in Cesarean Section and the Maternal Gut Microbiome: Protocol for a Remote Observational Cohort Study. [PDF]

JMIR Res Protoc
Feles EA, Mattner F.
europepmc   +1 more source

Nosocomial Outbreak of <i>Ralstonia pickettii</i> Infections Likely Linked to Saline Solutions in Germany from August 2023 to March 2024-Challenges in Medical Product-Related Outbreaks. [PDF]

Microorganisms
Sandfort M, von Laer A, Kampmeier S, Eichhorn I, Wolf SA, Driller M, Bajić V, Sedaghatjoo S, Fuchs S, Engelhart S, Mutters NT, Cónsul-Tejero EP, Zündorf J, Eckmanns T, Hogardt M, Haller S.   +15 more
europepmc   +1 more source

Liver-derived Indian hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis. [PDF]

Mol Metab
Teperino R, Adamová M, Aljabali SM, Pai S, Gerlini R, Paez-Perez I, Matz-Soja M, Heyne S, Lempradl A, Basilicata MF, Hrabě de Angelis M, Gebhardt R, Schleicher E, Häring HU, Pospisilik JA.   +14 more
europepmc   +1 more source