Results 191 to 200 of about 122,607 (246)

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Liver-derived Indian hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis. [PDF]

Mol Metab
Teperino R, Adamová M, Aljabali SM, Pai S, Gerlini R, Paez-Perez I, Matz-Soja M, Heyne S, Lempradl A, Basilicata MF, Hrabě de Angelis M, Gebhardt R, Schleicher E, Häring HU, Pospisilik JA.   +14 more
europepmc   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt. [PDF]

Sci Adv
Prallet S, Maier N, Li A, Afting C, Huang HE, Hu J, Toprak E, Keya DP, Colasanti O, León-Janampa N, Marlet J, Beisel C, Mogler C, Puchas P, Behrendt P, Boettler T, Steinmann E, Saha S, Laketa V, Lohmann V, Wittbrodt J, Hermann C, Dill MT, Dao Thi VL.   +23 more
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Monocytes acquire a tumor-associated IL1B program upon encountering patient-derived colon cancer organoids. [PDF]

Oncoimmunology
Balzasch BM, von Kries A, Hüll S, Shaltiel IA, Boonekamp KE, Ast V, Burgermeister E, Betge J, Ebert M, Boutros M, Helming L, Umansky V, Cerwenka A.   +12 more
europepmc   +1 more source

Annual Report 2016-17 [PDF]

, 2017
Houston Academy of Medicine - Texas Medical Center Library
core   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer. [PDF]

Signal Transduct Target Ther
Suarez-Carmona M, Hampel M, Zhang XW, Pöchmann A, Grauling-Halama SA, Valous NA, Charoentong P, Ferber D, Wissfeld J, Höflich A, Goriely S, Detavernier A, Azouz A, Rongvaux A, Zukunft S, Fleming I, Okun JG, Baracos V, Heikenwalder M, Zitvogel L, Xu X, Xu C, Volkmar M, Schraivogel D, Steinmetz L, Hamanishi J, Mandai M, Gaida M, Mokry T, Nattenmüller J, Sedlaczek O, Monje N, Schwab R, Hasenburg A, Mavratzas A, Boger RJ, Marmé F, Schott S, Halama N.   +38 more
europepmc   +1 more source