Results 201 to 210 of about 122,607 (246)

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor. [PDF]

Nat Commun
Renner M, Oleś M, Paramasivam N, Heilig CE, Schneider A, Modugno C, Herremans C, Hüllein J, Hutter B, Erkut C, Mock A, Krieghoff-Henning E, Jensen CB, Sakhteman A, The M, Prinz T, Lajer P, Baude-Müller A, Beck K, Beuthien-Baumann B, Apostolidis L, Bauer S, Boerries M, Brandts CH, Rieke DT, Kindler T, Klauschen F, Schulze-Osthoff K, Schlenk RF, Berchem G, Allgäuer M, Mechtersheimer G, Stenzinger A, Lipka DB, Schlesner M, Kuster B, Jahn A, Schröck E, Heining C, Teleanu MV, Horak P, Kreutzfeldt S, Hübschmann D, Hartmann W, Glimm H, Fröhling S.   +45 more
europepmc   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

New insights into the molecular basis of gametogenesis in the hybridogenetic water frog Pelophylax esculentus. [PDF]

Sci Rep
Plötner M, Meixner M, Poustka AJ, Grau JH, Theusner S, Liere K, Schüllermann T, Doležálková-Kaštánková M, Choleva L, Plötner J.   +9 more
europepmc   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma. [PDF]

Nat Cancer
Czernilofsky F, Mathioudaki A, Jopp-Saile L, Lutz R, Vonficht D, Wang X, Schniederjohann C, Voehringer H, Roider T, Baertsch MA, Rodemer C, Löffler-Wirth H, Grau M, Fitzgerald D, Mammen J, Kosla J, Liebers N, Bruch PM, Ordoñez-Rueda D, Brobeil A, Mechtersheimer G, Pabst C, Müller-Tidow C, Trumpp A, Seifert M, Neumann F, Heikenwälder M, Benes V, Huber W, Distler J, Lenz G, Binder H, Siebert R, Nolan GP, Gerstung M, Zaugg JB, Hübschmann D, Haas S, Dietrich S.   +38 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Csf1r-mediated depletion of midbrain microglia prevents dopaminergic neuron loss during chronic colitis

Kutscherauer RK, Andert M, Stolzer I, Neumaier EE, Dedden M, Kielkowski P, Xiang W, Grotemeyer A, Prinz M, Masuda T, Knobeloch K, Rothhammer V, Zundler S, Schlachetzki JC, Winkler J, Günther C, Süß P.   +16 more
europepmc   +1 more source

Dissection of the T cell infiltrate in mouse pancreatic tumors reveals an extensive and diverse tumor-reactive T cell repertoire. [PDF]

Sci Adv
Kehm H, Zens S, Baumann D, Meng Z, de Ru AH, Tjokrodirijo RTN, Vent C, Murawjew O, Braun S, Weiss A, Bieberich F, Konrad A, Lucato F, Kühner J, Minguez SG, Tan CL, Förster JD, Salek M, Riemer AB, Volkmar M, van Veelen P, Poschke I, Offringa R.   +22 more
europepmc   +1 more source