Results 201 to 210 of about 16,417,253 (231)

Multiplex Panel Detects Glial and Inflammatory Biomarker Signatures in Sporadic and C9orf72-ALS. [PDF]

Neurol Neuroimmunol Neuroinflamm
Baskar K, Steffke C, Bernsen S, Elmas Z, Hesebeck-Brinckmann J, Schuster J, Meyer T, Weydt P, Weishaupt J, Brenner D, Catanese A.   +10 more
europepmc   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Insights Into the Interplay Between the Senescent Cells and Immune Cells. [PDF]

Aging Cell
Jaros M, Schmidt M, Neubert L, Kamp JC, von Vietinghoff S, Bräsen JH, Schmitt R, Melk A.   +7 more
europepmc   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Exogenous dsRNA made accessible to Dicer by two eukaryotic RNA-dependent RNA polymerases in Paramecium tetraurelia. [PDF]

Commun Biol
Pirritano M, Buescher J, Staubach P, Tacken T, Yakovleva Y, Sabura M, Shehu K, Franzenburg S, Schneider M, Simon M.   +9 more
europepmc   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Low reporting quality limits the contribution of human organ models to COVID-19 research: a systematic review. [PDF]

EBioMedicine
Hülsemann M, Kniffert S, Löwa A, Baumgardt M, Hönzke K, Vallone VF, Drude NI, Stüdemann T, Ali ASM, Arroyo Araujo M, Bannach-Brown A, Brunotte L, Faist A, Fatykhova D, Fischer M, Hellwig L, Hinse S, Kessler M, Carlisle BG, Khankeh S, Dhamrait IS, Klein C, Koceva H, Kumar S, Kurreck J, Ludwik KA, Mergenthaler P, Schmerbeck SS, Singh S, Teixeira Alves LG, Wyler E, Stachelscheid H, Hippenstiel S, Toelch U, Hocke AC.   +34 more
europepmc   +1 more source

Prognostic value of circulating tumor DNA and copy-number alterations in patients receiving tandem [²²⁵Ac]Ac-/[¹⁷⁷Lu]Lu-PSMA-617 therapy for metastatic castration-resistant prostate cancer: a prospective observational study. [PDF]

BMC Cancer
Amghar M, Hielscher T, Rausch T, Özgür H, Bauder-Wüst U, Rathke H, Bruchertseifer F, Morgenstern A, Roscher M, Beneš V, Kratochwil C, Benešová-Schäfer M.   +11 more
europepmc   +1 more source

Analysis of Surface Immunoglobulin Expression in Burkitt Lymphoma Reveals a Subset of IgA-Expressing Cases Enriched at Mucosal Sites and Surface Immunoglobulin-Undetectable Cases: Insights into the Mutational Landscape. [PDF]

Cancers (Basel)
Siciliano MC, Lori C, Vannucchi M, Amato T, Bertolazzi G, Guazzo R, Noel O, Onyuma T, Granai M, Boccacci R, Grace K, Peter O, Onsongo S, Georgina M, Wedaga SP, Foster K, Mildred H, Joshua N, Fischer A, Bellan C, Siebert R, Leoncini L, Lazzi S.   +22 more
europepmc   +1 more source

De novo genome assembly of Ansell's mole-rat (Fukomys anselli). [PDF]

G3 (Bethesda)
Bekavac M, Coimbra R, Busa VF, Behm M, Wagner RE, Goncalves A, Begall S, Frye M, Odom DT.   +8 more
europepmc   +1 more source