Results 211 to 220 of about 122,607 (246)

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Diagnostic whole transcriptome sequencing in a series of 1233 FFPE solid tumor samples. [PDF]

Br J Cancer
Ball M, Beck S, Wlochowitz D, Fuchs T, Lorenz K, Zgorzelski C, Pallares Robles A, Allgäuer M, Volckmar AL, Goldschmid H, Ourailidis I, Brandt R, Christopoulos P, Thomas M, Seker-Cin H, Fink A, Schnecko F, Neumann O, Menzel M, Kirchner M, Fioretos T, Schirmacher P, Peters S, Budczies J, Stenzinger A, Kazdal D.   +25 more
europepmc   +1 more source

The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus

Advanced Science, EarlyView.
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang, Zijin Liu, Minshan Jin, Junting Liu, Shihao Wei, Dengmao Yang, Saiqi Yang, Yuan Guo, Mingxun Chen   +8 more
wiley   +1 more source

Promoter hypomethylation drives ABCB1-mediated carfilzomib resistance in multiple myeloma. [PDF]

Clin Epigenetics
Han S, Haertle L, Munawar U, Truger M, Hainold AS, Lee CY, Kurian S, Verbruggen C, Nerreter S, Vogt C, Besant E, Rein N, Lehmann J, Köppel M, Tamamushi Y, Zhou X, Steinbrunn T, Haaf T, Küster B, Slaby O, Haferlach C, Einsele H, Rasche L, Waldschmidt J, Besse A, Driessen C, Besse L, Kortüm KM.   +27 more
europepmc   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON). [PDF]

Hum Genomics
Abolhassani A, Alawathurage TM, Schmidt A, Brand F, Kilarski LL, Altmann H, Dahl E, Frank S, Göpel S, Hanses F, Hellmuth JC, Herr C, Kaasch AJ, Kobbe R, Konik MJ, Pink I, Römmele C, Rupp J, Scheer CS, Schneider MA, Stellbrink C, Stubbe HC, Tepasse PR, Teufel A, Vadász I, Vehreschild MJGT, Witzenrath M, Anton G, Bröhl I, Herold S, Illig T, Jiru-Hillmann S, Krawitz P, Mitrov L, Philipsen A, Pütz SM, Noethen MM, Nuernberg P, Reese JP, Riess O, Schreiber S, Schultze J, Steinbeis F, Vehreschild JJ, Wildberg C, Ludwig KU, Schulte EC.   +46 more
europepmc   +1 more source

Integrating Radiomics and Computational Pathology to Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma and Uncover Its Biological Basis in Tumor Microenvironment

Advanced Science, EarlyView.
Accurate prediction of early recurrence in pancreatic ductal adenocarcinoma is vital for optimizing treatment. A novel, integrated radiomics‐pathology machine learning model successfully forecasts recurrence risks by analyzing preoperative CT images and computational pathology.
Sihang Cheng, Fuze Cong, Shenbo Zhang, Rui Lv, Wenjia Zhang, Xinyi Ke, Juncheng Wu, Zhonghe Zhao, Kui Zhao, Di Dong, Ruofan Zhang, Zhengyu Jin, Max Seidensticker, Zhiwei Wang, Huanwen Wu, Xianlin Han, Nan Hong, Huadan Xue   +17 more
wiley   +1 more source

The bladder cancer m⁶A landscape is defined by global methylation dilution and focal 3'-UTR hypermethylation. [PDF]

EMBO Rep
Koch J, Xu J, Bormann F, Coutinho Carneiro V, Neuberger M, Nitschke K, Nientiedt M, Erben P, Michel MS, Rodriguez-Paredes M, Lyko F.   +10 more
europepmc   +1 more source

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Advanced Science, EarlyView.
This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu, Xingyu Zhang, Jingjia Zhang, Gaohui Huang, Chen Zhou, Chunlin Li, Xiaojun Huang, Jianbo Xiao, Nianjie Feng, Yuanbin She   +9 more
wiley   +1 more source

Whole-genome sequencing of Lassa virus from dry blood spots: a comparative evaluation. [PDF]

Infect Dis Poverty
Bangura U, Davis C, Dahl A, Klemroth S, Thomson E, Magassouba N', Fichet-Calvet E.   +6 more
europepmc   +1 more source