Results 161 to 170 of about 8,866 (208)

Serendipitous and Systematic Chemoproteomic Discovery of MBLAC2, HINT1, and NME1-4 Inhibitors from Histone Deacetylase-Targeting Pharmacophores. [PDF]

ACS Chem Biol
Lechner S, Sha S, Sethiya JP, Szczupak P, Dolot R, Lomada S, Sakhteman A, Tushaus J, Prokofeva P, Krauss M, Breu F, Vögerl K, Morgenstern M, German Mouse Clinic Consortium, Hrabě de Angelis M, Haucke V, Wieland T, Wagner C, Médard G, Bracher F, Kuster B.   +20 more
europepmc   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

COGNITION-GUIDE - Genomics-Guided Targeted Post-Neoadjuvant Therapy in Patients with Early Breast Cancer: Study Design of a Multicenter, Open-Label, Umbrella Phase II Study.

Geburtshilfe Frauenheilkd
Pixberg C, Maurer C, Smetanay K, Straßl L, Hlevnjak M, Zapatka M, Wagner CV, Yazdanparast H, Kurzawa J, Erben V, Feng F, Hong C, Hübschmann D, Buschhorn L, Suppelna JP, Michel L, Heublein S, Fremd C, Zivanovic O, Sinn P, Stenzinger A, Haidinger R, Schumacher-Wulf E, Ditsch N, Loibl S, Fröhling S, Link T, Wimberger P, Blohmer JU, Huebner H, Fasching PA, Janni W, Schlenk RF, Thewes V, Lichter P, Schneeweiss A.   +35 more
europepmc   +1 more source

Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory. [PDF]

Stem Cell Reports
Zikmund T, Fiorentino J, Penfold C, Stock M, Shpudeiko P, Agarwal G, Langfeld L, Petrova K, Peshkin L, Hamperl S, Scialdone A, Hoermanseder E.   +11 more
europepmc   +1 more source

Single‐Cell RNA Sequencing Identifies MMP11+ Cancer‐Associated Fibroblasts as Drivers of Angiogenesis and Bladder Cancer Progression

Advanced Science, EarlyView.
Single‐cell RNA sequencing identifies MMP11⁺ CAFs as pro‐angiogenic cells accumulating during bladder cancer progression. These cells promote angiogenesis by regulating ESM1⁺ tip endothelial cells and recruiting SPP1⁺ macrophages. Tumor‐derived BMP2 promotes their activation.
Wuwu Xu, Ting Liang, Hu Fang, Lu Fu, Dashi Deng, Xiyang Tan, Lisha Liu, Dongdong Tang, Haoxiang Zheng, Qiuxia Ding, Xiuqi Hou, Daquan Feng, Tao Tao, Song Wu   +13 more
wiley   +1 more source

A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages. [PDF]

Nat Commun
Schmerer N, Janga H, Aillaud M, Hoffmann J, Aznaourova M, Wende S, Steding H, Halder LD, Uhl M, Boldt F, Stiewe T, Nist A, Jerrentrup L, Kirschbaum A, Ruppert C, Rossbach O, Ntini E, Marsico A, Valasarajan C, Backofen R, Linne U, Pullamsetti SS, Schmeck B, Schulte LN.   +23 more
europepmc   +1 more source

TaPPR13, a Pentatricopeptide Repeat Protein Gene Activated by TaBZR2, Confers Drought Stress Tolerance by Enhancing the Antioxidant Defense System and Promoting Retrograde Signaling in Wheat (Triticum aestivum)

Advanced Science, EarlyView.
TaPPR13, a PPR protein family gene in wheat is activated by TaBZR2 to enhance drought stress tolerance and photosynthetic capacity. It achieves this by interacting with TaAOR1 and TaSIG5 to improve antioxidant defense and regulate chloroplast gene expression. Abstract The wheat (Triticum aestivum) brassinazole‐resistant 2 (TaBZR2) gene is identified as
Ze‐Hao Hou, Wei‐Jun Zheng, Lei Zheng, Jing‐Yue Wang, Shuang‐Xi Zhang, Ji‐Tong Wei, Shu‐Hui Yang, Yuan‐Chen Jiao, Wen‐Jing Cheng, Tai‐Fei Yu, Xiao‐Fei Ma, Jing‐Na Ru, Yong‐Wei Liu, Xin‐You Cao, Jun Chen, Yong‐Bin Zhou, Ming Chen, Li‐Hui Li, You‐Zhi Ma, Xiao‐Jun Nie, Zhao‐Shi Xu   +20 more
wiley   +1 more source

Memory-like Natural Killer Cell and CD19 Antibody-Based Immunotherapy in Combination with Tyrosine Kinase Inhibition Has Antitumor Effects against Ph(-like) Acute Lymphoblastic Leukemia. [PDF]

Cancer Immunol Res
Eskandarian Z, Hauch R, Schuster S, Winterberg D, Grabellus H, Imelmann C, Heitmann AL, Goos M, Rudloff K, Strauss J, Wolters-Eisfeld G, Nollau P, Klausz K, Schüller U, Peipp M, Spohn M, Horstmann MA.   +16 more
europepmc   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution. [PDF]

Nat Commun
de Faria FW, Riedel NC, Münter D, Interlandi M, Göbel C, Altendorf L, Richter M, Melcher V, Thomas C, Roy R, Schoof M, Bedzhov I, Moreno N, Graf M, Hotfilder M, Holdhof D, Hartmann W, Bruns AK, Brentrup A, Liesche-Starnecker F, Maerkl B, Sandmann S, Varghese J, Dugas M, Pinto PH, Balbach ST, Lu IN, Rossig C, Soehnlein O, Canak A, Ebinger M, Schuhmann M, Schittenhelm J, Frühwald MF, Schüller U, Albert TK, Walter C, Bruder JM, Kerl K.   +38 more
europepmc   +1 more source