Results 201 to 210 of about 133,668 (277)

Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia. [PDF]

Nat Commun
Prummel KD, Woods K, Kholmatov M, Schmitt EC, Vlachou EP, Labyadh M, Wehner R, Poschmann G, Stühler K, Winter S, Oelschlaegel U, Wobus M, Schwartz LS, Moura PL, Hellström-Lindberg E, Rajalingam K, Theobald M, Trowbridge JJ, Carron C, Jaffredo T, Schmitz M, Platzbecker U, Zaugg JB, Guezguez B.   +23 more
europepmc   +1 more source

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

<i>Bacillus anthracis</i> Phylogeography: Origin of the East Asian Polytomy and Impact of International Trade for Its near Global Dispersal. [PDF]

Pathogens
Vergnaud G, Antwerpen MH, Grass G.
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Age and Sex Effects on Blood Retrotransposable Element Expression Levels: Findings From the Population-Based Rhineland Study. [PDF]

Aging Cell
Talevi V, Lee HM, Liu D, Beyer MD, Salomoni P, Breteler MMB, Aziz NA.   +6 more
europepmc   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

Genome-wide association study identifies <i>ABCG1</i> as a susceptibility locus for tick-borne encephalitis. [PDF]

iScience
Gampawar PG, Sagmeister MG, Růžek D, Schweintzger NA, Hofer E, Kohlmaier B, Švendová V, Bogovič P, Zajkowska JM, Krbková L, Štruncová V, Mickienė A, Kohlfürst DS, Sonnleitner A, Fořtová A, Berankova M, Pychova M, Zavadska D, Sallah N, Pichler A, Sedláček D, Chrdle A, Haudum C, Obermayer-Pietsch B, Hoffmann P, Nöthen MM, Tammesoo ML, Metspalu A, Husa P, Stiasny K, Binder A, Berghold A, Strle F, Hibberd ML, Zenz W, EU-TICK-BO study group.   +35 more
europepmc   +1 more source

CircLRBA Promotes Epithelial‐Mesenchymal Transition, Immune Evasion, Chemoimmunotherapy Resistance and Metastasis Through Stabilizing Twist1

Advanced Science, EarlyView.
CircLRBA is highly expressed in breast cancer (BC) and associated with poor overall survival. Zeb1 mediated circLRBA facilitates BC cell proliferation, invasion, docetaxel (DTX) resistance and inhibits the infiltration of CD8+ T cell. CircLRBA could combine with SPOP to suppress the Twist1 ubiquitination degradation and enhances PD‐L1 transcription ...
Xiaosong Wang, Xin Yang, Lei Xing, Hang Chen, Fuming Xie, Bin Wang, Bowen Shi, Yan Yang, Junxia Chen   +8 more
wiley   +1 more source

Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression. [PDF]

Nat Commun
Foerster LC, Kaya O, Wüst V, Danciu DP, Akcay V, Bekavac M, Ziegler KC, Stinchcombe N, Tang A, Kleber S, Tang JLY, Brunken J, Lois-Bermejo I, Gesteira-Perez N, Ma X, Sadik A, Le PU, Petrecca K, Opitz CA, Liu H, Wirtz CR, Goncalves A, Marciniak-Czochra A, Anders S, Martin-Villalba A.   +24 more
europepmc   +1 more source

A GLUTAMATE CYSTEINE LIGASE Gene StGSH1 Regulated by StERF10 Enhanced Glutathione Accumulation and Adaptation to Low Phosphorus Stress in Potato

Advanced Science, EarlyView.
The StERF10‐StGSH1 module coordinates glutathione (GSH) biosynthesis under low‐phosphorus stress. The low‐phosphate‐induced AP2/ERF transcription factor StERF10 directly activates the transcription of StGSH1 and enhances GSH accumulation. Consequently, GSH scavenges reactive oxygen species and provides sulfur for sulfolipid synthesis, facilitating the ...
Xiaocheng Tian, Mingjun Li, Xiaojia Huang, Markus Wirtz, Xiaohui Zheng, Shilong Fan, Jiang Tian, Shaoqun Liu, Zhonghua Liu, Hongbo Zhao   +9 more
wiley   +1 more source