Results 181 to 190 of about 351,337 (287)

Impact of frailty on postoperative delirium in ICU patients aged 65 and older: a systematic review. [PDF]

BMJ Open
Schindele D, McDonough J, Müller-Wolff T.   +2 more
europepmc   +1 more source

BioCNTs Mediated Delivery of Systemically Mobile Small RNAs via Leaf Spray to Control Both Tomato DNA and RNA Viruses

Advanced Science, EarlyView.
A carbon nanotube‐based biopesticide system (BioCNTs) enables efficient delivery and systemic movement of RNAi molecules to control major tomato viruses. By integrating shRNA and tRNA‐like structures (TLS) with BioCNTs, this green and scalable approach achieves long‐term silencing and high antiviral efficacy through simple foliar spraying.
Xuedong Liu, Xiaofei Liang, Zipeng Cai, Zheng Liu, Xuefeng Wang, Changyong Zhou, Mengji Cao, Sijia Liu   +7 more
wiley   +1 more source

Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations. [PDF]

Nat Genet
Tangermann C, Ghosh A, Ziegler M, Facchinetti F, Stappenbeck J, Carus Sahin YO, Riester M, Viardot LC, Zundel T, Friboulet L, Hollebecque A, Naveja JJ, Wanninger A, Hess ME, Brummer T, Boerries M, Loges S, Loriot Y, Illert AL, Diederichs S.   +19 more
europepmc   +1 more source

Changing the Face of Medicine Library Programs, Vol.21 (4) April - June 2008 [PDF]

, 2008
Houston Academy of Medicine-Texas Medical Center Library
core   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

A Reflection on Current Definitions of Critical Care and Critical Illness-A Narrative Review of the Literature. [PDF]

Nurs Crit Care
Sterr F, Gerlach A, Creemers C, Pietsch S, Berkemeier J, Özlü I, Papacek-Zimmermann C, Bauernfeind L, Division for Critical Care Nursing, German Society of Nursing Science.   +9 more
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

International Case Studies to Identify Success Factors and Contextual Conditions in the Digital Transformation of Health Care Systems and Derive Lessons for Germany: Study Protocol for a Mixed Methods Study.

JMIR Res Protoc
Kraft L, Brecher AL, Sgraja S, Busse R, Amelung VE.   +4 more
europepmc   +1 more source

Genie in the bottle? a qualitative study of general practitioners' perspectives and information needs concerning digital mental health applications in Germany. [PDF]

BMC Prim Care
Sahan F, Panitz K, Wagenaar C, Kairies-Schwarz N, Vomhof M, Zinn M, Guthardt L, Bau J, Loerbroks A, Pischke CR, Apolinário-Hagen J.   +10 more
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source