Results 181 to 190 of about 41,715 (245)

The Use of Mobile Apps in Adolescent Psychotherapy: Assessment of Psychotherapists' Perspectives. [PDF]

JMIR Form Res
Wüllner S, Hermenau K, Hecker T, Siniatchkin M.   +3 more
europepmc   +1 more source

The SlDOF9‐SlSWEET17 Module: a Switch for Controlling Sugar Distribution Between Nematode Induced Galls and Roots in Tomato

Advanced Science, EarlyView.
Root‐knot nematode (RKN) disease seriously affects the yield and quality of vegetable crops. SlDOF9‐SlSWEET17 model helps plants resist RKN infection during early stage by switching off the sugar transport capacity of other SlSWEET proteins that are hijacked by RKNs.
Xiaoyun Wang, Zhimei Wang, Xinyue Tang, Jiamei Qin, Xiaoxuan Zhou, Lixia Gu, Huihui Bian, Lulu Sun, Huang Huang, Rui Yang, Jianli Wang, Shaohui Wang, Shuangchen Chen, Zhongren Yang, Wenchao Zhao   +14 more
wiley   +1 more source

Inflammatory signaling pathways play a role in SYK inhibitor resistant AML. [PDF]

Sci Rep
Tausch S, Villinger C, Alexe G, Urban DJ, Shen M, Jahn D, Vischedyk J, Scheich S, Serve H, Hall MD, Stegmaier K, Oellerich T, Cremer A.   +12 more
europepmc   +1 more source

FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single‐Cell Perspective

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals distinct immune responses to FLASH versus conventional dose rate irradiation in early radiation‐induced lung injury. FLASH irradiation reduces Ccrl2⁺ neutrophil infiltration, activates CD4⁺ CD40L⁺ Th cells, restrains pro‐inflammatory Mefv⁺ monocytes, and enhances epithelial repair via TGF‐β signaling, underscoring its
Hao Lu, Menghua Li, Cheng Quan, Caihui Li, Dawei Li, Zhihui Li, Jing Xu, Lihui Zhang, Qixiang Liu, Guofu Dong, Changzhen Wang   +10 more
wiley   +1 more source

German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway. [PDF]

Geroscience
Kolbe D, Dose J, Putter P, Ziemann M, Laudes M, Regeneron Genetics Center, Slagboom PE, Franke A, Deelen J, Nebel A.   +9 more
europepmc   +1 more source

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

Advanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang, Xiaoshuang Niu, Ye Su, Xiaoyun Ye, Wanqiong Li, Wenxuan Zeng, Xin Zhao, Zhuoying He, Qingyu Dong, Xiuman Zhou, Xinghua Sui, Guanyu Chen, Yanfeng Gao, Juan Liu   +13 more
wiley   +1 more source

Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines. [PDF]

Nat Commun
Kasan M, Geyer FH, Siebenlist J, Sill M, Öllinger R, Faehling T, de Álava E, Surdez D, Dirksen U, Oehme I, Scotlandi K, Delattre O, Müller-Nurasyid M, Rad R, Strauch K, Grünewald TGP, Cidre-Aranaz F.   +16 more
europepmc   +1 more source

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

Advanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su   +7 more
wiley   +1 more source

Toward a Domain-Overarching Metadata Schema for Making Health Research Studies FAIR (Findable, Accessible, Interoperable, and Reusable): Development of the NFDI4Health Metadata Schema.

JMIR Med Inform
Abaza H, Shutsko A, Klopfenstein SAI, Vorisek CN, Schmidt CO, Brünings-Kuppe C, Clemens V, Darms J, Hanß S, Intemann T, Jannasch F, Kasbohm E, Lindstädt B, Löbe M, Nimptsch K, Nöthlings U, Ocanto MG, Osei TB, Perrar I, Peters M, Pischon T, Sax U, Schulze MB, Schwarz F, Schwedhelm C, Thun S, Waltemath D, Zeleke AA, Müller W, Golebiewski M.   +29 more
europepmc   +1 more source