Results 241 to 250 of about 351,337 (287)

Prevalence and correlates of self-reported and accelerometer-determined sedentary behavior and physical activity of German university students: cross-sectional results of the SmartMoving study. [PDF]

BMC Public Health
Hoffmann SW, Helten J, Loss J, Germelmann CC, Tittlbach S.   +4 more
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Translation and validation of the artificial intelligence anxiety scale in German. [PDF]

PLoS One
Hajek A, Zwar L, Neumann A, Gyasi RM, Yon DK, Pengpid S, Peltzer K, König HH.   +7 more
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Quality assessment of clinical practice guidelines for sepsis and variations in recommendations. [PDF]

BMC Infect Dis
Li HY, Jiang SL, Wang J, Wang HS, Wang LH.   +4 more
europepmc   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

Genome-wide association study identifies <i>ABCG1</i> as a susceptibility locus for tick-borne encephalitis. [PDF]

iScience
Gampawar PG, Sagmeister MG, Růžek D, Schweintzger NA, Hofer E, Kohlmaier B, Švendová V, Bogovič P, Zajkowska JM, Krbková L, Štruncová V, Mickienė A, Kohlfürst DS, Sonnleitner A, Fořtová A, Berankova M, Pychova M, Zavadska D, Sallah N, Pichler A, Sedláček D, Chrdle A, Haudum C, Obermayer-Pietsch B, Hoffmann P, Nöthen MM, Tammesoo ML, Metspalu A, Husa P, Stiasny K, Binder A, Berghold A, Strle F, Hibberd ML, Zenz W, EU-TICK-BO study group.   +35 more
europepmc   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Representativeness of a German AI-enabled data network for secondary epidemiological analysis based on electronic health records. [PDF]

PLoS One
Eichhorn S, Mitze FN, Wagner F, Seuthe IMC, Brinks R, Zimmermann A, Dastur M, Ladenbauer J, Park JJ.   +8 more
europepmc   +1 more source

Karl Ludwig Giesecke : his albums and his likely involvement in the writing of the libretto of Mozart's opera The Magic Flute [PDF]

, 2009
Whittaker, Alfred
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