Results 171 to 180 of about 1,018,571 (313)

Socionics: Sociological Concepts for Social Systems of Artificial (and Human) Agents [PDF]

Socionics is an interdisciplinary approach with the objective to use sociological knowledge about the structures, mechanisms and processes of social interaction and social communication as a source of inspiration for the development of multi-agent ...
Ingo Schulz-Schaeffer, Thomas Malsch
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

PEtab-GUI: a graphical user interface to create, edit, and inspect PEtab parameter estimation problems. [PDF]

Bioinformatics
Jost PJ, Bergmann FT, Weindl D, Hasenauer J.   +3 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Echocardiographic strain imaging and progression of atrial fibrillation in low-risk individuals. [PDF]

Int J Cardiol Heart Vasc
Ohlrogge AH, Seum F, van Vreeswijk NL, Csengeri D, Sinning C, Linz D, Rienstra M, Schnabel RB.   +7 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Brain atrophy patterns in anti-IgLON5 disease. [PDF]

Brain
Yogeshwar SM, Bartels F, Grüter T, Muñiz-Castrillo S, Picard G, Crijnen YS, Bernard E, Heidbreder A, Zekeridou A, Ringelstein M, Kraft A, Kovac S, Wandinger KP, de Vries JM, Boon AJW, Veenbergen S, Geis C, Penner L, Melzer N, Leypoldt F, Blaabjerg M, Pittock SJ, Gaig C, Sabater L, Santamaria J, Graus F, Dalmau J, Prüss H, Höftberger R, Schreiner B, McKeon A, Lewerenz J, Irani S, Mignot E, Titulaer MJ, Ayzenberg I, Honnorat J, Finke C, IgLON5 Imaging Consortium .   +38 more
europepmc   +1 more source

Student micro-publications in archival tradition-building. Project funding by the German Research Foundation

Authors: Dennis Hormuth and Gunnar B. Zimmermann At universities, students make up the largest group of people – at the University of Hamburg, for example, with over 42,000 enrolled students in the 2022/2023 academic year, compared to around 15,000 employees, including over 9,000 employees at the University Medical Center.
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source