Results 171 to 180 of about 215,077 (307)

Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer

The Journal of Clinical Investigation
BACKGROUND Despite an overall poor prognosis, about 15% of patients with advanced-stage tubo-ovarian high-grade serous carcinoma (HGSC) survive 10 or more years after standard treatment.METHODS We evaluated the tumor microenvironment of this exceptional,
Brad H. Nelson, Phineas Hamilton, Minh Tung Phung, Katy Milne, Bronwyn Harris, Shelby Thornton, Donald Stevens, Shreena Kalaria, Karanvir Singh, Céline M. Laumont, Elena Moss, Aliya Alimujiang, Nicola S. Meagher, Adelyn Bolithon, Sian Fereday, Catherine J. Kennedy, Joy Hendley, Dinuka Ariyaratne, Kathryn Alsop, Nadia Traficante, Ellen L. Goode, Anthony Karnezis, Hui Shen, Jean Richardson, Cindy McKinnonDeurloo, Anne Chase, Bronwyn Grout, Jennifer Anne Doherty, Holly R. Harris, Kara L. Cushing-Haugen, Michael Anglesio, Karolin Heinze, David Huntsman, Aline Talhouk, Gillian E. Hanley, Jennifer Alsop, Mercedes Jimenez-Linan, Paul D.P. Pharoah, Jessica Boros, Alison H. Brand, Paul R. Harnett, Raghwa Sharma, Jonathan L. Hecht, Naoko Sasamoto, Kathryn L. Terry, Beth Karlan, Jenny Lester, Michael E. Carney, Marc T. Goodman, Brenda Y. Hernandez, Lynne R. Wilkens, Sabine Behrens, Renée Turzanski Fortner, Peter A. Fasching, Christiani Bisinotto, Francisco José Candido dos Reis, Prafull Ghatage, Martin Köbel, Esther Elishaev, Francesmary Modugno, Linda Cook, Nhu Le, Aleksandra Gentry-Maharaj, Usha Menon, María J. García, Cristina Rodriguez-Antona, Kyo Farrington, Linda E. Kelemen, Stefan Kommoss, Annette Staebler, Dale W. Garsed, James D. Brenton, Anna M. Piskorz, David D.L. Bowtell, Anna DeFazio, Susan J. Ramus, Malcolm C. Pike, Celeste Leigh Pearce   +77 more
doaj   +1 more source

Fine Particulate Exposure During Pregnancy Impacts on Perinatal Complications in Deeply Phenotyped Preterm Infants With Significant Immaturity. [PDF]

Pulm Circ
Johansson C, Kraus Y, Sanchez JDH, Schubert B, Wolf K, Voss C, Stoeger T, Seegmüller T, Flemmer AW, Förster K, Standl M, Hilgendorff A.   +11 more
europepmc   +1 more source

German Research Foundation approves collaborative research center for soft-matter simulations [PDF]

MRS Bulletin, 2014
openaire   +1 more source

Data tracking and DEAL: On the 2022/2023 negotiations and the consequences for academic libraries

The article „Data tracking and DEAL: On the 2022/2023 negotiations and the consequences for academic libraries” discusses the problem of data tracking in academic libraries in the context of the German DEAL negotiations with the academic publishers ...
Dittmann, Jana, Mittermaier, Bernhard, Ludwig, Judith, Altschaffel, Robert, Beurskens, Michael, Kiltz, Stefan, Horstmann, Wolfram, Bilic-Merdes, Michaela, Stump, Katrin, Lauer, Gerhard   +9 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Immunoadsorption in dilated cardiomyopathy: the IASO-DCM trial. [PDF]

Eur Heart J
Felix SB, Böhm M, Braun-Dullaeus RC, Caforio ALP, Erdmann E, Grabmaier U, Groß S, Klingel K, Knebel F, Lehnert K, Mahabadi AA, Mitrovic V, Nauck M, Nickening G, Noutsias M, Sandek A, Schultheiss HP, Schulze C, Schunkert H, Seferovic PM, Stangl K, Staudt A, Tschöpe C, Wachter R, Wegner D, Werdan K, Waagstein F, Hjalmarson Å, Dörr M.   +28 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

DNA origami-based virus-like particles: a new class of HIV vaccine candidates with superior immunogenic properties. [PDF]

Signal Transduct Target Ther
Muecksch F, Hamdan J, Fackler OT.
europepmc   +1 more source

CoARA Action Plan 2024 of Deutsche Forschungsgemeinschaft e.V. (DFG, German Research Foundation)

This is the CoARA Action Plan published by the German Research Foundation (DFG, Deutsche Forschungsgemeinschaft) in 2024.
openaire   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source