Results 171 to 180 of about 1,022,480 (312)

Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer

The Journal of Clinical Investigation
BACKGROUND Despite an overall poor prognosis, about 15% of patients with advanced-stage tubo-ovarian high-grade serous carcinoma (HGSC) survive 10 or more years after standard treatment.METHODS We evaluated the tumor microenvironment of this exceptional,
Brad H. Nelson, Phineas Hamilton, Minh Tung Phung, Katy Milne, Bronwyn Harris, Shelby Thornton, Donald Stevens, Shreena Kalaria, Karanvir Singh, Céline M. Laumont, Elena Moss, Aliya Alimujiang, Nicola S. Meagher, Adelyn Bolithon, Sian Fereday, Catherine J. Kennedy, Joy Hendley, Dinuka Ariyaratne, Kathryn Alsop, Nadia Traficante, Ellen L. Goode, Anthony Karnezis, Hui Shen, Jean Richardson, Cindy McKinnonDeurloo, Anne Chase, Bronwyn Grout, Jennifer Anne Doherty, Holly R. Harris, Kara L. Cushing-Haugen, Michael Anglesio, Karolin Heinze, David Huntsman, Aline Talhouk, Gillian E. Hanley, Jennifer Alsop, Mercedes Jimenez-Linan, Paul D.P. Pharoah, Jessica Boros, Alison H. Brand, Paul R. Harnett, Raghwa Sharma, Jonathan L. Hecht, Naoko Sasamoto, Kathryn L. Terry, Beth Karlan, Jenny Lester, Michael E. Carney, Marc T. Goodman, Brenda Y. Hernandez, Lynne R. Wilkens, Sabine Behrens, Renée Turzanski Fortner, Peter A. Fasching, Christiani Bisinotto, Francisco José Candido dos Reis, Prafull Ghatage, Martin Köbel, Esther Elishaev, Francesmary Modugno, Linda Cook, Nhu Le, Aleksandra Gentry-Maharaj, Usha Menon, María J. García, Cristina Rodriguez-Antona, Kyo Farrington, Linda E. Kelemen, Stefan Kommoss, Annette Staebler, Dale W. Garsed, James D. Brenton, Anna M. Piskorz, David D.L. Bowtell, Anna DeFazio, Susan J. Ramus, Malcolm C. Pike, Celeste Leigh Pearce   +77 more
doaj   +1 more source

HISTAI: a valuable dataset with a valuable lesson. [PDF]

J Pathol Clin Res
Hewitt KJ, Reitsam NG, Foersch S, Erber R, Zeng Q, Kather JN.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

deepmriprep: voxel-based morphometry preprocessing via deep neural networks. [PDF]

Nat Comput Sci
Fisch L, Winter NR, Goltermann J, Barkhau C, Emden D, Ernsting J, Konowski M, Leenings R, Borgers T, Flinkenflügel K, Grotegerd D, Kraus A, Leehr EJ, Meinert S, Stein F, Teutenberg L, Thomas-Odenthal F, Usemann P, Hermesdorf M, Jamalabadi H, Jansen A, Nenadić I, Straube B, Kircher T, Berger K, Risse B, Dannlowski U, Hahn T.   +27 more
europepmc   +1 more source

The Research Data Centre of the German Federal Employment Agency: data supply and demand between 2004 and 2009 [PDF]

"The Research Data Centre (FDZ) of the German Federal Employment Agency (BA) in the Institute for Employment Research (IAB) was founded in 2004 and is intended mainly to facilitate access to BA and IAB microdata for non-commercial empirical research ...
Heining, Jörg
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Deep learning-based H&E-derived risk scores in colorectal cancer: associations with tumour morphology, biology, and predicted drug response. [PDF]

J Pathol
Reitsam NG, Jiang X, Liang J, Grosser B, Grozdanov V, Loeffler CM, Gustav M, Lenz T, Muti HS, Carrero ZI, West NP, Quirke P, Foersch S, Jesinghaus M, Müller W, Yuan T, Hoffmeister M, Brenner H, Jonnagaddala J, Hawkins NJ, Ward RL, Grabsch HI, Märkl B, Kather JN.   +23 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation. [PDF]

Eur Heart J
Fakuade FE, Gronwald J, Brandes P, Döring Y, Rubio T, Seibertz F, Knierim M, Abu-Taha IH, El-Essawi A, Jebran AF, Danner BC, Baraki H, Kamler M, Kutschka I, Heijman J, Dobrev D, Schmidt C, Kallenberger SM, Voigt N.   +18 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source