Results 51 to 60 of about 215,077 (307)

Investigations on SARS-CoV-2 Susceptibility of Domestic and Wild Animals Using Primary Cell Culture Models Derived from the Upper and Lower Respiratory Tract

Viruses, 2022
Several animal species are susceptible to SARS-CoV-2 infection, as documented by case reports and serological and in vivo infection studies. However, the susceptibility of many animal species remains unknown.
Iris Färber, Johannes Krüger, Cheila Rocha, Federico Armando, Maren von Köckritz-Blickwede, Stefan Pöhlmann, Armin Braun, Wolfgang Baumgärtner, Sandra Runft, Nadine Krüger   +9 more
doaj   +1 more source

Slow publishing in the age of 'fast-food'

, 2021
Rapid publication seems like an obvious imperative for scientific debate in the digital era. Most, if not all, science publishers aim to shorten the process between first submission and final publication of articles.
Meyer, Carsten, Dawson, Michael N., Bourguet, Denis, Hortal, Joaquín   +3 more
core   +1 more source

A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction [PDF]

, 2022
The Hedgehog (Hh) cascade is central to development, tissue homeostasis and cancer. A pivotal step in Hh signal transduction is the activation of glioma-associated (GLI) transcription factors by the atypical G protein-coupled receptor (GPCR) SMOOTHENED ...
Olivieri, Cristina, Hedeen, Danielle S., Hedeen, Danielle S, Taylor, Susan S, Arveseth, Corvin D, Bröckel, Jan W, Bruystens, Jessica, King, CC, Happ, John T, Zhang, Jingyi, Taylor, Susan S. T., Capener, Jacob L, Zhu, Ju-Fen, Bröckel, Jan W., Veglia, Gianluigi, Myers, Benjamin R, Happ, John T., King, C. C., Vu, Lily, Ruiz-Perez, Victor L, Arveseth, Corvin D., Bertinetti, Daniela, Herberg, Friedrich W, Herberg, Friedrich W., Myers, Benjamin R., Nelson, Isaac B., Capener, Jacob L., Nelson, Isaac B, Ruiz-Pérez, Victor L., Ge, Xuecai   +29 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Před 150 lety byl založen germanistický seminář na pražské univerzitě [PDF]

Časopis pro Moderní Filologii
The article deals with one chapter in the history of German Studies as a scholarly pursuit at the University of Prague. Specifically it attempts to describe the circumstances of the foundation of the Department of German Studies in 1874 and its ...
Lenka Vodrážková
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Research for assessment, not deployment, of Climate Engineering: The German Research Foundation's Priority Program SPP 1689

Earth's Future, 2017
The historical developments are reviewed that have led from a bottom–up responsibility initiative of concerned scientists to the emergence of a nationwide interdisciplinary Priority Program on the assessment of Climate Engineering (CE) funded by the German Research Foundation (DFG).
Andreas Oschlies, Gernot Klepper
openaire   +2 more sources

Co‐production of nature's contributions to people: What evidence is out there? [PDF]

, 2023
© 2023 The Authors. People and Nature published by John Wiley & Sons Ltd on behalf of British Ecological Society.1. Nature's contributions to people (NCP) rarely originate from nature alone.
María R. Felipe‐Lucia, Berta Martín‐López, Aletta Bonn, Roman Isaac, Martín‐López, Berta, Felipe‐Lucia, María R., Jana Kachler, Kachler, Jana, Martín-López, Berta, Bonn, Aletta, Isaac, Roman, Felipe Lucía, María   +11 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Characterising a homozygous two‐exon deletion in UQCRH: comparing human and mouse phenotypes

EMBO Molecular Medicine, 2021
Mitochondrial disorders are clinically and genetically diverse, with isolated complex III (CIII) deficiency being relatively rare. Here, we describe two affected cousins, presenting with recurrent episodes of severe lactic acidosis, hyperammonaemia ...
Silvia Vidali, Raffaele Gerlini, Kyle Thompson, Jill E Urquhart, Jana Meisterknecht, Juan Antonio Aguilar‐Pimentel, Oana V Amarie, Lore Becker, Catherine Breen, Julia Calzada‐Wack, Nirav F Chhabra, Yi‐Li Cho, Patricia da Silva‐Buttkus, René G Feichtinger, Kristine Gampe, Lillian Garrett, Kai P Hoefig, Sabine M Hölter, Elisabeth Jameson, Tanja Klein‐Rodewald, Stefanie Leuchtenberger, Susan Marschall, Philipp Mayer‐Kuckuk, Gregor Miller, Manuela A Oestereicher, Kristina Pfannes, Birgit Rathkolb, Jan Rozman, Charlotte Sanders, Nadine Spielmann, Claudia Stoeger, Marten Szibor, Irina Treise, John H Walter, Wolfgang Wurst, Johannes A Mayr, Helmut Fuchs, Ulrich Gärtner, Ilka Wittig, Robert W Taylor, William G Newman, Holger Prokisch, Valerie Gailus‐Durner, Martin Hrabě de Angelis   +43 more
doaj   +1 more source