Results 61 to 70 of about 215,077 (307)

Tree girdling provides insight on the role of labile carbon in nitrogen partitioning between soil microorganisms and adult European beech

, 2009
Dannenmann, M. et al.-- 10 pages, 1 figure, 2 tables, 60 references.Nitrogen (N) cycling in terrestrial ecosystems is complex since it involves the closely interwoven processes of both N uptake by plants and microbial turnover of a variety of N ...
Papen, Hans, Dannenmann, M., Knicker, Heike   +2 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

DeepGreen – DeepGold: Open-Access-Transformation – Entwicklung und Perspektiven

GMS Medizin – Bibliothek – Information, 2019
The DeepGreen project () is developing an automated workflow to transfer scholarly publications from publishers to repositories for open access publishing.
Rusch, Beate, Boltze, Julia, Dierkes, Thomas, Goltz-Fellgiebel, Julia Alexandra, Staub, Hedda   +4 more
doaj   +1 more source

Long-read transcriptome sequencing of CLL and MDS patients uncovers molecular effects of SF3B1 mutations [PDF]

Mutations in splicing factor 3B subunit 1 (SF3B1) frequently occur in patients with chronic lymphocytic leukemia (CLL) and myelodysplastic syndromes (MDSs). These mutations have different effects on the disease prognosis with beneficial effect in MDS and
Gattermann, Norbert, Grimm, Christina, Heß, Felix, Pacholewska, Alicja, König, Julian, Lienhard, Matthias, Brüggemann, Mirko, Königs, Anja, Zarnack, Kathi, Kaiser, Jesko, Hallek, Michael, Schweiger, Michal R., Bilalli, Lorina, Becker, Kerstin, Herwig, Ralf, Köhrer, Karl, Herling, Carmen D., Gohlke, Holger, Hänel, Heike   +18 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Impaired mitochondrial ketone body oxidation in insulin resistant statesResearch in context

EBioMedicine
Summary: Background: Reduced mitochondrial respiratory function has been implicated in metabolic disorders like type 2 diabetes (T2D), obesity, and metabolic dysfunction-associated steatotic liver disease (MASLD), which are tightly linked to insulin ...
Elric Zweck, Sarah Piel, Johannes W. Schmidt, Daniel Scheiber, Martin Schön, Sabine Kahl, Volker Burkart, Bedair Dewidar, Ricarda Remus, Alexandra Chadt, Hadi Al-Hasani, Lucia Mastrototaro, Hug Aubin, Udo Boeken, Artur Lichtenberg, Jörg Distler, Amin Polzin, Malte Kelm, Ralf Westenfeld, Robert Wagner, Patrick Schrauwen, Julia Szendroedi, Michael Roden, Cesare Granata   +23 more
doaj   +1 more source

The relationship between acceptance, fatigue, and subjective cognitive impairment in hematologic cancer survivors.

, 2018
Background/Objective: Cancer and its treatment can have a detrimental impact on psychological well-being. Acceptance as the basis of acceptance and commitment therapy (ACT) has shown beneficial effects on depression and anxiety. However, its relationship
Esser, Peter, Mehnert, Anja, Kuba, Katharina, Weißflog, Gregor, Garcia-Torres, Francisco, Gotze, Heide   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Utilization of psychotherapy, pharmacotherapy, and their combination by individuals with current or residual depression: results from five annual nationally representative German surveys

Scientific Reports
Depression is a common and burdensome mental disorder affecting more than 320 million people worldwide. Clinical practice guidelines recommend psychotherapy, antidepressant pharmacotherapy, or their combination as the cornerstones of evidence-based ...
Louisa Breuer, Andreas Czaplicki, Ulrich Hegerl, Hanna Reich   +3 more
doaj   +1 more source

Optically induced indirect photonic transitions in a slow light photonic crystal waveguide

, 2014
M.C.M., A.Y.P. and M.E. acknowledge the support of the German Research Foundation under Grant EI 391/13-2, and appreciate the support of CST, Darmstadt, Germany, with their Finite Integration Software Microwave Studio. J.L.
Munoz, Michel Castellanos, Li, Juntao, O'Faolain, Liam, Krauss, Thomas F., Eich, Manfred, Petrov, Alexander Yu., Castellanos Muñoz, Michel   +6 more
core   +1 more source