Results 61 to 70 of about 1,018,571 (313)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

DeepGreen – DeepGold: Open-Access-Transformation – Entwicklung und Perspektiven

GMS Medizin – Bibliothek – Information, 2019
The DeepGreen project () is developing an automated workflow to transfer scholarly publications from publishers to repositories for open access publishing.
Rusch, Beate, Boltze, Julia, Dierkes, Thomas, Goltz-Fellgiebel, Julia Alexandra, Staub, Hedda   +4 more
doaj   +1 more source

Characterising a homozygous two‐exon deletion in UQCRH: comparing human and mouse phenotypes

EMBO Molecular Medicine, 2021
Mitochondrial disorders are clinically and genetically diverse, with isolated complex III (CIII) deficiency being relatively rare. Here, we describe two affected cousins, presenting with recurrent episodes of severe lactic acidosis, hyperammonaemia ...
Silvia Vidali, Raffaele Gerlini, Kyle Thompson, Jill E Urquhart, Jana Meisterknecht, Juan Antonio Aguilar‐Pimentel, Oana V Amarie, Lore Becker, Catherine Breen, Julia Calzada‐Wack, Nirav F Chhabra, Yi‐Li Cho, Patricia da Silva‐Buttkus, René G Feichtinger, Kristine Gampe, Lillian Garrett, Kai P Hoefig, Sabine M Hölter, Elisabeth Jameson, Tanja Klein‐Rodewald, Stefanie Leuchtenberger, Susan Marschall, Philipp Mayer‐Kuckuk, Gregor Miller, Manuela A Oestereicher, Kristina Pfannes, Birgit Rathkolb, Jan Rozman, Charlotte Sanders, Nadine Spielmann, Claudia Stoeger, Marten Szibor, Irina Treise, John H Walter, Wolfgang Wurst, Johannes A Mayr, Helmut Fuchs, Ulrich Gärtner, Ilka Wittig, Robert W Taylor, William G Newman, Holger Prokisch, Valerie Gailus‐Durner, Martin Hrabě de Angelis   +43 more
doaj   +1 more source

Combined 3D characterization of porous zeolites by STEM and FIB tomography [PDF]

, 2014
German Research Foundation Priority Program 1570German Research Foundation Cluster of Excellence EXC 315 “Engineering of Advanced ...
Beltrán, Ana M., Machoke, Albert Gonche, Przybilla, Thomas, Schwieger, Wilhelm, Spiecker, Erdmann, Winter, B.   +5 more
core  

The Phylogenetic Likelihood Library [PDF]

, 2015
[Abstract] We introduce the Phylogenetic Likelihood Library (PLL), a highly optimized application programming interface for developing likelihood-based phylogenetic inference and postanalysis software.
Aberer, Andre J., Darriba, Diego, Flouri, Tomas, Haeseler, Arndt von, Izquierdo-Carrasco, F., Minh, B.Q., Nguyen, Lam-Tung, Stamatakis, Alexandros   +7 more
core   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Impaired mitochondrial ketone body oxidation in insulin resistant statesResearch in context

EBioMedicine
Summary: Background: Reduced mitochondrial respiratory function has been implicated in metabolic disorders like type 2 diabetes (T2D), obesity, and metabolic dysfunction-associated steatotic liver disease (MASLD), which are tightly linked to insulin ...
Elric Zweck, Sarah Piel, Johannes W. Schmidt, Daniel Scheiber, Martin Schön, Sabine Kahl, Volker Burkart, Bedair Dewidar, Ricarda Remus, Alexandra Chadt, Hadi Al-Hasani, Lucia Mastrototaro, Hug Aubin, Udo Boeken, Artur Lichtenberg, Jörg Distler, Amin Polzin, Malte Kelm, Ralf Westenfeld, Robert Wagner, Patrick Schrauwen, Julia Szendroedi, Michael Roden, Cesare Granata   +23 more
doaj   +1 more source

S-layers at second glance? Altiarchaeal grappling hooks (hami) resemble archaeal S-layer proteins in structure and sequence [PDF]

, 2018
This is the final version of the article. Available from Frontiers Media via the DOI in this recordResearch on SM1-MSI was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft), grant no. MO 1977/3-1 given to CM-E.
Ahmed, M, Auerbach, A, Bellack, A, Daum, B, Gribaldo, S, Klingl, A, Kolb-Lenz, D, Leitinger, G, Moissl-Eichinger, C, Mora, M, Perras, AK, Probst, AJ, Takahashi, LK, Wanner, G, Ziegler, C   +14 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Utilization of psychotherapy, pharmacotherapy, and their combination by individuals with current or residual depression: results from five annual nationally representative German surveys

Scientific Reports
Depression is a common and burdensome mental disorder affecting more than 320 million people worldwide. Clinical practice guidelines recommend psychotherapy, antidepressant pharmacotherapy, or their combination as the cornerstones of evidence-based ...
Louisa Breuer, Andreas Czaplicki, Ulrich Hegerl, Hanna Reich   +3 more
doaj   +1 more source