Results 41 to 50 of about 15,002 (266)
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Мінеральні ресурси УкраїниThis article is about the chemical element germanium, which has become one of the most important materials today. Germanium, which is a trace element, was isolated mainly from the products of other mines and from ore rocks.
M. S. Burlutskyy
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Mechanism of Extracting Germanium from Ge-Containing Solution with Tannins
Metals, 2023 The process of germanium–tannin complex is the oldest form of technology for extracting germanium from Ge-containing solutions. This reaction mechanism is relatively controversial as it imposes restrictions on ideas and methods for reducing the amount of
Yan Hong +4 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Kuangchan zonghe liyongThis is an article in the field of mineral engineering. Germanium ore is an indispensable strategic rare metal resource in the fields of information and communication, modern aviation, military, new energy and many other high-tech fields.
Sujiang ZHANG +2 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
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Prospects and possibilities of germanium extraction from the Bigan coal deposit
Мінеральні ресурси УкраїниThe article is devoted to lignite deposits of Zakarpattia, which contain germanium, in particular, the Bigan deposit and methods of extracting germanium from this deposit.
M. S. Burlutskyy, S. F. Lytvyniuk
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source