Results 211 to 220 of about 7,045,371 (336)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The Effect of Unilateral Cervical Sympathectomy on Reactions of the Skin11The experiments here reported were carried out in the University Clinic for Dermatology and Venereal Diseases in Breslau, Germany (Directors: Geheimrat J. Jadassohn, Prof. M. Jessner).

, 1940
Hans Biberstein
openalex   +1 more source

GERMAN EAST AFRICA DURING THE WAR1 [PDF]

, 1917
J. H. Y. Briggs
openalex   +1 more source

Personalized Combined Nutrition & Exercise Intervention in Newly Diagnosed Cancer Patients - a Trial Protocol. [PDF]

Future Sci OA
Theurich S, Niels T, Baurecht H, Welker C, Tomanek A, Schmidt-Wolf I, Greil C, Luley K, Forstmeyer D, Jahn P, Ockenga J, Jensen W, Graf K, Wiskemann J, Fiorentini C, Zoth N, Leitzmann M, Baumann FT, INTEGRATION Study Consortium.   +18 more
europepmc   +1 more source

Tuberculosis in Germany [PDF]

Proceedings of the National Academy of Sciences, 1948
openaire   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Vascular access for initial treatment of adult emergency patients in the resuscitation room: short summary of recommendations from the German national S1 guideline. [PDF]

Int J Emerg Med
Struck MF, Bieler D, Henck A, Hermes C, Kegel M, Klein M, Kümpers P, Michalski D, Bernhard M.   +8 more
europepmc   +1 more source

Political Economy in Germany [PDF]

, 1905
Gustav Cohn
openalex   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source