Results 341 to 350 of about 3,782,491 (387)

The germinal center reaction

Journal of Allergy and Clinical Immunology, 2010
The germinal center (GC) reaction is the basis of T-dependent humoral immunity against foreign pathogens and the ultimate expression of the adaptive immune response. GCs represent a unique collaboration between proliferating antigen-specific B cells, T follicular helper cells, and the specialized follicular dendritic cells that constitutively occupy ...
Dominique, Gatto, Robert, Brink
openaire   +2 more sources

Getting toGether in Germinal centers

Science Immunology, 2021
Ggt5 cleaves the ligand of P2RY8 in lymph node follicles and generates a gradient that supports B cell confinement to germinal centers.
Liat Stoler-Barak, Ziv Shulman
openaire   +2 more sources

Germinal centers develop oligoclonally

European Journal of Immunology, 1987
AbstractAs part of our studies into the role of germinal centers, we investigated whether each de novo generated germinal center (GC) develops from one single GC precursor cell (GCPC, monoclonal development), a few GCPC (oligoclonal development) or from many GCPC (polyclonal development).
Kroese, FGM, Wubbena, AS, Seijen, HG, Nieuwenhuis, P   +3 more
openaire   +3 more sources

The Germinal Center Response

Critical Reviews in Immunology, 2004
The germinal center reaction is the foundation of T-cell-dependent humoral responses. Antigen-specific B cells recruited into germinal centers undergo a complex cellular program that allows for extensive expansion, isotype switching, somatic hypermutation, and differentiation into antibody-forming cells and memory cells.
Kristy L, Wolniak, Stephen M, Shinall, Thomas J, Waldschmidt   +2 more
openaire   +2 more sources

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.

Circulation, 2019
BACKGROUND Atherosclerosis progression is modulated by interactions with the adaptive immune system. Humoral immunity can help protect against atherosclerosis formation; however, the existence, origin, and function of putative atherogenic antibodies are ...
M. Centa, Hong Jin, L. Hofste, S. Hellberg, A. Busch, R. Baumgartner, Nienke J Verzaal, Sara Lind Enoksson, Ljubica Perisic Matic, S. Boddul, D. Atzler, Daniel Y. Li, Changyan Sun, G. Hansson, D. Ketelhuth, U. Hedin, F. Wermeling, E. Lutgens, C. Binder, Lars Maegdesfessel, S. Malin   +20 more
semanticscholar   +1 more source

Plasma cell differentiation during the germinal center reaction

Immunological Reviews, 2019
Germinal centers (GCs) are formed in secondary lymphoid tissues upon immunization with T‐dependent antigens. In GCs, somatic hypermutation generates B cells with increased antibody affinity and these high‐affinity B cells preferentially differentiate ...
W. Ise, T. Kurosaki
semanticscholar   +1 more source

Germinal Center Survival

Science, 2010
The humoral immune response, which comprises antibodies secreted by B lymphocytes, is critical for protection against pathogens. In response to infection, B lymphocytes proliferate and differentiate into antibody-producing effector cells.
openaire   +2 more sources

Immunosenescence and germinal center reaction

Immunological Reviews, 1997
Summary: Dysfunction of the immune system in aged individuals includes at least two important factors: accumulation of immunocytes with reduced function and accumulation of lymphocyte clones with self‐reactive potential. Coincidently, there is a profound reduction of the germinal center reaction in the aged.
B, Zheng, S, Han, Y, Takahashi, G, Kelsoe   +3 more
openaire   +2 more sources

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

Nature, 2021
Jackson S Turner, Jane A O'halloran, Wooseob Kim   +2 more
exaly  

The germinal centre B cell response to SARS-CoV-2

Nature Reviews Immunology, 2021
Brian J Laidlaw, Ali H Ellebedy
exaly