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Critical Reviews in Immunology, 2004
The germinal center reaction is the foundation of T-cell-dependent humoral responses. Antigen-specific B cells recruited into germinal centers undergo a complex cellular program that allows for extensive expansion, isotype switching, somatic hypermutation, and differentiation into antibody-forming cells and memory cells.
Kristy L. Wolniak +2 more
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The germinal center reaction is the foundation of T-cell-dependent humoral responses. Antigen-specific B cells recruited into germinal centers undergo a complex cellular program that allows for extensive expansion, isotype switching, somatic hypermutation, and differentiation into antibody-forming cells and memory cells.
Kristy L. Wolniak +2 more
openaire +3 more sources
Current Opinion in Hematology, 2001
The germinal center reaction is one critical outcome of helper T-cell-dependent antigen-specific B-cell responses. Germinal center reactions are the culmination of an orchestrated series of intercellular information exchanges discussed here as the serial synapsis model of adaptive immunity.
Michael G. McHeyzer-Williams +2 more
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The germinal center reaction is one critical outcome of helper T-cell-dependent antigen-specific B-cell responses. Germinal center reactions are the culmination of an orchestrated series of intercellular information exchanges discussed here as the serial synapsis model of adaptive immunity.
Michael G. McHeyzer-Williams +2 more
openaire +3 more sources
Annual Review of Immunology, 1994
Germinal centers develop in the B cell follicles of secondary lymphoid tissues during T cell-dependent (TD) antibody responses. The B cells that give rise to germinal centers initially have to be activated outside follicles, in the T cell-rich zones in association with interdigitating cells and T cell help.
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Germinal centers develop in the B cell follicles of secondary lymphoid tissues during T cell-dependent (TD) antibody responses. The B cells that give rise to germinal centers initially have to be activated outside follicles, in the T cell-rich zones in association with interdigitating cells and T cell help.
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Getting toGether in Germinal centers
Science Immunology, 2021Ggt5 cleaves the ligand of P2RY8 in lymph node follicles and generates a gradient that supports B cell confinement to germinal centers.
Liat Stoler-Barak, Ziv Shulman
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Science, 2010
The humoral immune response, which comprises antibodies secreted by B lymphocytes, is critical for protection against pathogens. In response to infection, B lymphocytes proliferate and differentiate into antibody-producing effector cells.
Caroline Ash, Maria Cruz
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The humoral immune response, which comprises antibodies secreted by B lymphocytes, is critical for protection against pathogens. In response to infection, B lymphocytes proliferate and differentiate into antibody-producing effector cells.
Caroline Ash, Maria Cruz
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Complement-in’ the germinal center response
Nature Immunology, 2021B cells rewire complement for optimal germinal center responses. When B cell C3 activity is limited, germinal centers collapse and outputs are impaired.
Marcus James Robinson +2 more
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Germinal centers develop oligoclonally
European Journal of Immunology, 1987AbstractAs part of our studies into the role of germinal centers, we investigated whether each de novo generated germinal center (GC) develops from one single GC precursor cell (GCPC, monoclonal development), a few GCPC (oligoclonal development) or from many GCPC (polyclonal development).
Auk S. Wubbena +3 more
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Functional anatomy of germinal centers
American Journal of Anatomy, 1984AbstractThis year we celebrate the first centennial of the discovery of germinal centers by Flemming in 1884. The present paper reviews and adds new data to the functional anatomy of a germinal center. Emphasizing its reactive nature, we first describe a germinal center reaction and then deal with its infrastructural aspects and constituent cell ...
Paul Nieuwenhuis, Davina Opstelten
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Repulsive behavior in germinal centers
Science, 2017B cell–T cell interactions are terminated by EPH receptors and ...
G. Leandros Moschovakis +1 more
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The life and death of the germinal center
Annals of Diagnostic Pathology, 2020The formation, development and dissolution of germinal centers is a major part of immune system function. It is important to differentiate neoplastic processes from follicular hyperplasia and regressive follicular changes. Better understanding of germinal center development and dissolution also provides diagnostic clues to the underlying pathologic ...
Robert S. Ohgami +4 more
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