Results 351 to 360 of about 3,656,698 (369)

The dynamic structure of the germinal center

Immunology Today, 1998
Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur.
Claudia Berek, Marie Kosco-Vilbois, Stephanie A. Camacho   +2 more
openaire   +3 more sources

Germinal center or nongerminal center DLBCL?

Nature Reviews Clinical Oncology, 2009
Patients with a immunohistochemically defined, germinal-center tumor subtype have an improved outcome compared with patients with the non-germinal-center phenotype when treated with CHOP only, according to a prospective study. The benefit was not observed in those treated with the rituximab combination therapy.
Gerhard Held, Michael Pfreundschuh
openaire   +2 more sources

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.

Circulation, 2019
BACKGROUND Atherosclerosis progression is modulated by interactions with the adaptive immune system. Humoral immunity can help protect against atherosclerosis formation; however, the existence, origin, and function of putative atherogenic antibodies are ...
M. Centa, Hong Jin, L. Hofste, S. Hellberg, A. Busch, R. Baumgartner, Nienke J Verzaal, Sara Lind Enoksson, Ljubica Perisic Matic, S. Boddul, D. Atzler, Daniel Y. Li, Changyan Sun, G. Hansson, D. Ketelhuth, U. Hedin, F. Wermeling, E. Lutgens, C. Binder, Lars Maegdesfessel, S. Malin   +20 more
semanticscholar   +1 more source

The chilling origin of germinal centers

Science Immunology, 2023
Germinal center–like structures have been identified in ectothermic vertebrates, establishing germinal centers as a universal component of humoral immunity (see related Research Article by Shibasaki et al. )
openaire   +4 more sources

Immunosenescence and germinal center reaction

Immunological Reviews, 1997
Summary: Dysfunction of the immune system in aged individuals includes at least two important factors: accumulation of immunocytes with reduced function and accumulation of lymphocyte clones with self‐reactive potential. Coincidently, there is a profound reduction of the germinal center reaction in the aged.
Biao Zheng, Shuhua Han, Yoshimasa Takahashi, Garnett Kelsoe   +3 more
openaire   +3 more sources

Regulating the germinal center

Science, 2017
Immune Regulation Unregulated production of antibodies may contribute to the development of autoimmunity. In humans and mice, follicular regulatory T (Tfr) cells are thought to limit the germinal center reaction and reduce antibody production within B cell follicles. Yet how Tfr cells control the germinal center reaction is unclear. Ritvo et al.
openaire   +2 more sources

How to Simulate a Germinal Center

2017
Germinal centers host a mini-evolutionary environment where B cells can mutate their receptor and be selected depending on its affinity to target antigens in a process called affinity maturation. Starting from founder cells with a weak B cell receptor affinity, germinal centers release output cells as antibody-secreting cells or memory cells with a ...
Sebastian Binder, Ananya Rastogi, Philippe Robert, Michael Meyer-Hermann   +3 more
openaire   +3 more sources

To ‘B’ or not to ‘B’ a germinal center?

Immunology Today, 1997
Abstract Under certain pathological conditions, germinal centers (GCs) form in many atypical sites, such as the stomach, lung and synovial joints. Thus, understanding the cellular and molecular interactions leading to a GC response is relevant not only for protective immunity but also for possible therapeutic strategies.
Marie Kosco-Vilbois, Hanswalter Zentgraf, Johannes Gerdes, Jean-Yves Bonnefoy   +3 more
openaire   +3 more sources

Plasma cell differentiation during the germinal center reaction

Immunological Reviews, 2019
Germinal centers (GCs) are formed in secondary lymphoid tissues upon immunization with T‐dependent antigens. In GCs, somatic hypermutation generates B cells with increased antibody affinity and these high‐affinity B cells preferentially differentiate ...
W. Ise, T. Kurosaki
semanticscholar   +1 more source

The physiology of germinal centers.

Critical reviews in immunology, 1996
GCs contain Ag-induced rapidly proliferating B cell blasts called centroblasts and centrocytes and are located in primary follicles of peripheral lymphoid tissue. Their peak development is at 7 to 10 d after Ag. The generation of memory B cells occurs in GCs, accompanied by frequent Ig isotype switching, Ig gene V region somatic hypermutation, and/or ...
Tsiagbe VK, INGHIRAMI, Giorgio, Thorbecke G.J.   +2 more
openaire   +2 more sources