Results 241 to 250 of about 570,791 (339)

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

open access: yesAdvanced Science, EarlyView.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen   +17 more
wiley   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

open access: yesAdvanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng   +20 more
wiley   +1 more source

Biomimetic Adaptive Hydrothermal Balance Fabric‐Based Dual‐Interface Solar Evaporator for Efficient and Stable Desalination

open access: yesAdvanced Science, EarlyView.
This study combines the biological structure of octopuses with the “3D structure” of spacer fabrics to fabricate a dual‐interface solar evaporator with adaptive hydrothermal balance. Water adaptation is achieved through the differentiated design of the upper and lower layers, and dynamic hydrothermal balance is realized by dynamically regulating the ...
Ning Niu   +10 more
wiley   +1 more source

Moisture Harvesting by the Structure Regulation of Hygroscopic Hydrogel for Energy and Water Sustainability

open access: yesAdvanced Electronic Materials, EarlyView.
Hygroscopic hydrogels are capable of utilizing the moisture from air, which can transfer the gaseous water to liquid by a surface phase transition. Taking advantage of this water, sustainable water production, thermal management, and electricity generation can be realized.
Yujie Du   +5 more
wiley   +1 more source

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