Results 111 to 120 of about 340,349 (250)

Clinical outcomes and prognostic features of germline BRCA mutant breast cancer patients: single-center experience, Madinah, Saudi Arabia [PDF]

World Cancer Research Journal
Objective: The aim of this study is to evaluate the clinicopathological features and prognostic impact of breast cancer harboring germline BRCA1/2 mutation.
M. Aljahel, S. Alfotih, E. Fallatah, M. Amine Sekkel, O. Alharbi, A. Alshehri, Z. Jastaniah, T. Ahmed, N. Mulla, D. Alkhayat, M. Elbaiomy, B. Albondagji, H. Ghazi, M. Khoja, S. Abdelsalam, K. Alghamdi, E. Abokhalaf   +16 more
doaj   +1 more source

Human Germline Interventions–Think First [PDF]

Frontiers in Genetics, 2016
Recent studies using gene editing tools such as CRISPR/Cas9 have shown an enormously broad spectrum of possible future applications. This genetic engineering technique allows researchers to easily disable, insert, or replace DNA fragments, while raising risks such as incomplete or inaccurate editing, off-target mutations, and other unintended ...
openaire   +3 more sources

Behavioral Epigenetics: Perspectives Based on Experience-Dependent Epigenetic Inheritance

Epigenomes, 2019
Epigenetic regulation plays an important role in gene regulation, and epigenetic markers such as DNA methylation and histone modifications are generally described as switches that regulate gene expression.
You-Yuan Pang, Rita Jui-Hsien Lu, Pao-Yang Chen   +2 more
doaj   +1 more source

p53 activity is selectively licensed in the Drosophila stem cell compartment

eLife, 2014
Oncogenic stress provokes tumor suppression by p53 but the extent to which this regulatory axis is conserved remains unknown. Using a biosensor to visualize p53 action, we find that Drosophila p53 is selectively active in gonadal stem cells after ...
Annika Wylie, Wan-Jin Lu, Alejandro D’Brot, Michael Buszczak, John M Abrams   +4 more
doaj   +1 more source

Using Machine Learning and Natural Language Processing to Review and Classify the Medical Literature on Cancer Susceptibility Genes

, 2019
PURPOSE: The medical literature relevant to germline genetics is growing exponentially. Clinicians need tools monitoring and prioritizing the literature to understand the clinical implications of the pathogenic genetic variants.
Acevedo, Francisco, Armengol, Victor Diego, Bao, Yujia, Barzilay, Regina, Braun, Danielle, Deng, Zhengyi, Hughes, Kevin S, Kim, Heeyoon, Ouardaoui, Nofal, Parmigiani, Giovanni, Wang, Cathy, Wang, Yan   +11 more
core   +1 more source

Epidermal Growth Factor Receptor-mutated Lung Cancer as the Initial Manifestation of Germline TP53 Mutation Associated Cancer [PDF]

, 2018
Surabhi Pathak, Sunny Singh, Vatsala Katiyar, Susan McDunn   +3 more
openalex   +1 more source

Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors

Cell Reports, 2016
Elicitation of broadly neutralizing antibodies remains a long-standing goal of HIV vaccine research. Although such antibodies can arise during HIV-1 infection, gaps in our knowledge of their germline, pre-immune precursor forms, as well as on their ...
Christina Yacoob, Marie Pancera, Vladimir Vigdorovich, Brian G. Oliver, Jolene A. Glenn, Junli Feng, D. Noah Sather, Andrew T. McGuire, Leonidas Stamatatos   +8 more
doaj   +1 more source

Germline Transgenic Methods for Tracking Cells and Testing Gene Function During Regeneration in the Axolotl

, 2013
The salamander is the only tetrapod that regenerates complex body structures throughout life. Deciphering the underlying molecular processes of regeneration is fundamental for regenerative medicine and developmental biology, but the model organism had ...
Khattak, Shahryar, Schuez, Maritta, Richter, Tobias, Knapp, Dunja, Haigo, Saori L., Sandoval-Guzmán, Tatiana, Hradlikova, Kristyna, Duemmler, Annett, Kerney, Ryan R., Tanaka, Elly M.   +9 more
core   +3 more sources

The R2R3 MYB Transcription Factor DUO1 Activates a Male Germline-Specific Regulon Essential for Sperm Cell Differentiation inArabidopsis    [PDF]

, 2011
Michael Borg, Lynette Brownfield, Hoda Khatab, Anna Sidorova, Melanie Lingaya, David Twell   +5 more
openalex   +1 more source

Selective Recognition of Carbohydrate Antigens by Germline Antibodies Isolated from AID Knockout Mice [PDF]

, 2022
Andrew T. DeLaitsch, Jacey R. Pridgen, Avery Tytla, Megan L. Peach, Rayleen Hu, David W. Farnsworth, Aislinn K. McMillan, Natalie Flanagan, J. Sebastian Temme, Marc C. Nicklaus, Jeffrey C. Gildersleeve   +10 more
openalex   +1 more source