Results 91 to 100 of about 234,487 (302)

biowdl/germline-DNA: Release 2.0.0

, 2019
The bam-to-gvcf and jointgenotyping subworkflows were combined in a single gatk-variantcalling pipeline. This allowed for eliminating some inefficiencies that were caused by communication between these pipelines.
Peter van 't Hof, António Paulo, Ruben Vorderman, DavyCats, Leon Mei   +4 more
core   +1 more source

The Regulation of Human Germline Genome Modification in the People’s Republic of China

, 2020
China’s advances in the field together with the size of its scientific community and resources, position it at the forefront of biotechnological and gene editing research.
Song, Lingqiao, Rosario Isasi, Lingqiao Song, Isasi, Rosario   +3 more
core   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Pharmacogenomics in Oncology Care

Frontiers in Genetics, 2014
Cancer pharmacogenomics have contributed a number of important discoveries to current cancer treatment, changing the paradigm of treatment decisions. Both somatic and germline mutations are utilized to better understand the underlying biology of cancer ...
Kelly K Filipski, Leah E Mechanic, Rochelle eLong, Andrew N Freedman   +3 more
doaj   +1 more source

Germline-specific gene expression of DSB formation, repair and response genes is altered by chemical exposures.

, 2019
Expression levels of a panel of genes responsible for DSB formation, repair and DNA damage response were examined by quantitative RT-PCR in glp-1(bn18);col-121(nx3) worms that grow without a germline when shifted from 15°C (A) to 25°C (B).
Luciann Cuenca (6335483), Monica P. Colaiácovo (3215385), Nara Shin (173813), Rajendiran Karthikraj (4918135), Kurunthachalam Kannan (487986)   +4 more
core   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Evolutionarily conserved mechanisms of male germline development in flowering plants and animals [PDF]

, 2014
Sexual reproduction is the main reproductive strategy of the overwhelming majority of eukaryotes. This suggests that the last eukaryotic common ancestor was able to reproduce sexually.
Martinho, Rui Gonçalo, Navarro-Costa, Paulo, Pereira, Patrícia A., Becker, Jörg D.   +3 more
core   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Role of Hemocytes in the Aging of Drosophila Male Germline

Cells
Stem cells are essential for the proper functioning of tissues, replacing damaged, senescent cells to ensure tissue regeneration. However, as age advances, the number of these stem cells can change, and their self-renewal abilities can become impaired ...
Virginia Varga, Janka Szinyákovics, Anikó Bebes, Fanni Szikszai, Tibor Kovács   +4 more
doaj   +1 more source

Microarray analysis of single isolated cells of the female gametophyte reveals potential regulators of female germline development in Arabidopsis thaliana [PDF]

, 2013
This work has used single-cell isolation and transcriptome profiling to further our knowledge about the cells comprising the female gametophyte of Arabidopsis thaliana which have thus far been highly inaccessible.
Soljic, Lucija
core   +1 more source