Results 111 to 120 of about 234,487 (302)

Functional analysis of prostate cancer-associated germline variants in the kallikrein-3 gene [PDF]

, 2017
This thesis is a comprehensive analysis of two functional germline variants of prostate specific antigen (PSA), the current widely used biomarker for prostate cancer diagnosis.
Srinivasan, Srilakshmi
core   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Primordial Germ Cell-Mediated Chimera Technology Produces Viable Pure-Line Houbara Bustard Offspring: Potential for Repopulating an Endangered Species [PDF]

, 2010
BACKGROUND: The Houbara bustard (Chlamydotis undulata) is a wild seasonal breeding bird populating arid sandy semi-desert habitats in North Africa and the Middle East.
Liu Chunhai, Baskar, Vijay, Saleem Shazia, Chang, Il-Kuk, Ulrich Wernery, Vijay Baskar, Shazia Saleem, Saleem, Shazia, Chunhai Liu, Il-Kuk Chang, Guerineche, Zhor, Baskar Vijay, Khazanehdari, Kamal A., Kamal A. Khazanehdari, Wernery, Renate, Wernery Renate, Darren K Griffin, Milstone, David S., Zhor Guerineche, Griffin Darren K., Liu, Chunhai, Kinne, Jörg, Khazanehdari Kamal A., Darren K. Griffin, Renate Wernery, Guerineche Zhor, Kamal A Khazanehdari, Jörg Kinne, Wernery, Ulrich, Wernery Ulrich, Kinne Jörg, Griffin, Darren K., Chang Il-Kuk   +32 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

cancersysbio/germline-epitopes: v1.0

<h2>Release v1.0</h2> <p>Code repository of publication:<br> Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity (Houlahan et al., 2023)</p ...
Aziz Khan, Katie Houlahan
core   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source

NAVIGATING THE FUTURE IN A SEA OF CRISPR UNCERTAINTY

Zygon, 2020
Humanity's toolkit for altering the world we live in now includes CRISPR. Through an evolutionary process, bacteria acquired a way to protect themselves from an invading virus, making their immediate future more secure.
doaj   +2 more sources

Germline-encoded residues in the HCDR2 and HCDR3 mediate glycan contacts and are essential for free glycan binding.

, 2019
Alanines were substituted for germline-encoded amino acids identified in the DH501 structure to contact glycan (circles in Fig 3A; [37]). HCDR2 and HCDR3 substitutions are shown in cyan and purple respectively, with amino acid position indicated above ...
Barton F. Haynes (140266), Julia A. Jones (2930433), David C. Montefiori (7392644), Rachel K. Reed (8129862), Brian E. Watts (8129865), Baptiste Aussedat (1917181), Ashley M. Trama (8129871), William E. Walkowicz (6848114), Esther M. Lee (8129859), S. Munir Alam (164023), Nelson R. Wu (8129856), Nathan I. Nicely (779148), Fangping Cai (8129868), Kevin O. Saunders (7392623), Amanda Eaton (4850560)   +14 more
core   +1 more source