Results 81 to 90 of about 234,487 (302)

Human Germline Genome Editing [PDF]

The American Journal of Human Genetics, 2017
With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017.
Kelly E, Ormond, Douglas P, Mortlock, Derek T, Scholes, Yvonne, Bombard, Lawrence C, Brody, W Andrew, Faucett, Nanibaa' A, Garrison, Laura, Hercher, Rosario, Isasi, Anna, Middleton, Kiran, Musunuru, Daniel, Shriner, Alice, Virani, Caroline E, Young   +13 more
openaire   +2 more sources

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies

Viruses, 2009
Several human monoclonal antibodies (hmAbs) and antibody fragments, including the best characterized in terms of structure-function b12 and Fab X5, exhibit relatively potent and broad HIV-1 neutralizing activity.
Dimiter S. Dimitrov, Yang Feng, Weizao Chen, Xiaodong Xiao   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

biowdl/germline-DNA: Release 1.1.0

, 2019
Allow using csv table format samplesheet as input format. Update tasks so they pass the correct memory requirements to the execution engine. Memory requirements are set on a per-task (not per-core) basis.
Peter van 't Hof, António Paulo, Ruben Vorderman, DavyCats, Leon Mei   +4 more
core   +1 more source

Sequence changes in predicted promoter elements of STK11/LKB1 are unlikely to contribute to Peutz-Jeghers syndrome [PDF]

, 2005
Background: Germline mutations or large-scale deletions in the coding region and splice sites of STK11/LKB1 do not account for all cases of Peutz-Jeghers syndrome (PJS).
Anneke Lucassen, Lim, W., Lucassen Anneke, Norman, A., Taylor, R., Rohan Taylor, Tomlinson, I, Taylor, R, R. Phillips (7481324), Houlston Richard S, Phillips Robin, N.C.M Hearle (7633313), Tomlinson, I., Houlston, R.S., Houlston, RS, Norman, A, Norman Andrew, Murday, Victoria, Robin Phillips, Ian Tomlinson, Edwin Swarbrick, Lim, G., Lim, Guan, Trembath, Richard C., I. Tomlinson (7633316), V. Murday (7633319), O'Donohue, J, Hearle, Nicholas C.M., Morrison, Patrick J., Lim Guan, Murday, V, Lim, G, O'Donohue, John, Morrison, Patrick, Phillips, R., A. Lucassen (7633346), Hearle, N.C.M., Lucassen, A, Lim, W, O'Donohue John, O'Donohue, J., Hodgson, S., Trembath Richard C, Richard C. Trembath (7633334), Morrison, P J, Tomlinson, Ian, Murday, V., Lee, P., Lim Wendy, G. Lim (7633325), S. Hodgson (7633343), Lucassen, Anneke, P. Lee (7633328), Lucassen, A., Swarbrick Edwin, Andrew Norman, Hodgson, S, W. Lim (6499019), Peter Lee, Phillips, R, Hearle, N C M, Trembath, R C, Patrick J Morrison, Tomlinson Ian, Hodgson Shirley, Swarbrick, E., John O'Donohue, Lim, Wendy, Lee Peter, Swarbrick, E, Lee, P, Hearle Nicholas CM, Hodgson, Shirley, Shirley Hodgson, Trembath, RC, Richard S Houlston, Morrison Patrick J, R.S Houlston (7633349), Norman, Andrew, Nicholas CM Hearle, A. Norman (7633340), Taylor, Rohan, R. Taylor (2402647), Wendy Lim, Phillips, Robin, P.J. Morrison (7633337), Victoria Murday, E. Swarbrick (7633322), Richard C Trembath, Guan Lim, Hearle, NC, Morrison, PJ, Lee, Peter, Houlston, Richard S., Murday Victoria, J. O'Donohue (7633331), Taylor Rohan, Trembath, R.C., Swarbrick, Edwin, Houlston, R S   +99 more
core   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Germline-reverted VRC01 Fab binding to 426c Env variants produced in 293T and GnT1^- cells.

, 2018
Germline-reverted VRC01 Fab binding to 426c Env variants produced in 293T and GnT1- cells.
Barton F. Haynes (140266), James Peacock (5932133), Haili Tang (240284), Shay Behrens (5932130), Lautaro G. Perez (4225849), Tongqing Zhou (263499), Celia C. LaBranche (172138), Matthew D. Gray (59251), Kevin O. Saunders (372588), Andrew T. McGuire (106405), David C. Montefiori (108747), Hongmei Gao (240295), Quentin J. Sattentau (207789), John R. Mascola (229761), Kelli Greene (240291), Leonidas Stamatatos (106421), Amanda Eaton (4850560)   +16 more
core   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source