Results 211 to 220 of about 114,676 (292)

A Genome‐Wide Association Study of Colorectal Cancer Mortality Outcomes Among Individuals of African and Admixture Ancestry

Molecular Carcinogenesis, EarlyView.
ABSTRACT African Americans have the highest colorectal cancer (CRC) mortality rates in the United States. We performed the first genome‐wide association study (GWAS) of overall and CRC‐specific mortality among African Americans with incident CRC to identify genetic contributors to CRC outcomes.
Thomas Lawler, Jirong Long, Rene Welch, Irene Ong, Oluwatoyosi Ogunmuyiwa, Rida A. Khatri, Martha Shrubsole, Shaneda Warren Andersen   +7 more
wiley   +1 more source

Novel <i>LZTR1</i> germline mutation as a mechanism of resistance to osimertinib in <i>EGFR</i>-mutated lung adenocarcinoma: a case report. [PDF]

Transl Lung Cancer Res
Park W, Fricke J, Mambetsariev I, Velasquez G, Nadaf-Rahrov R, Dingal ST, Kim P, Babikian R, Amini A, Afkhami M, Salgia R.   +10 more
europepmc   +1 more source

VP2-2024: Fuzuloparib with or without apatinib in HER2- metastatic breast cancer (mBC) patients (pts) with germline BRCA1/2 mutations (gBRCA1/2m): A randomized phase III trial [PDF]

Hua Li, Jingyu Liu, Ying Liu, Q. Ouyang, Lingling Wang, Zhou Tong, Yuee Teng, Tao Sun, Xiaolin Wang, Jing Cheng, Xin Zhou, Lu Fanfan, Minhao Yan, Ji Nie, Carrie Ye, Z-M Shao, Yikai Wang, Xiaohong R. Yang, Eun‐Ji Song   +18 more
openalex   +1 more source

Custom scripts used in the study "Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome"

, 2020
Cai Li
openalex   +1 more source

Huntington's Disease and Huntington's Disease‐like 2 (HDL2) in Martinique

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Huntington's Disease‐like 2 (HDL2), caused by a CAG repeat expansion in JPH3, closely resembles HD. All reported HDL2 patients to date have some African ancestry. While both disorders exist in the Caribbean, their relative frequency and clinical characteristics remain largely unknown.
Ignacio Antolin‐Sanfeliz, Anna‐Gaelle Giguet‐Valard, Sophie Duclos, Cécile Cazeneuve, Chloé Angelini, Aïssatou Signaté, Russell L. Margolis, Cyril Goizet, Rémi Bellance   +8 more
wiley   +1 more source

Fertility Preservation in BRCA1/2 Germline Mutation Carriers: An Overview. [PDF]

Life (Basel)
Silvestris E, Cormio G, Loizzi V, Corrado G, Arezzo F, Petracca EA.   +5 more
europepmc   +1 more source

Molecular Diagnostics in Thyroid Nodules: Current Applications, Clinical Value, and Future Perspective

Med Research, EarlyView.
ABSTRACT Molecular diagnostics have become an important adjunct to ultrasonography and fine‐needle aspiration (FNA) for thyroid nodules, especially in Bethesda III/IV cytology where malignancy risk is uncertain. This narrative review summarizes the diagnostic and prognostic value of key genomic drivers (BRAF V600E, RAS, RET, TERT, and selected fusions)
Guohui Xiao, Min Ding, Zhixue Min, Yihan Dong, Xuanye Cao, Qiang Lu, Cong Chen, Yahui Wu, Xin Guo, Zhen Wu, Jing Xie, Dan Xu, Haizhen Chen, Rongli Xie, Jian Fei   +14 more
wiley   +1 more source

Correction for Zhu et al., Population size interacts with reproductive longevity to shape the germline mutation rate. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

, 2013
Jaime M. Ross, James B. Stewart, Erik Hagström, Stefan Brené, Arnaud Mourier, Giuseppe Coppotelli, Christoph Freyer, Marie Lagouge, Barry J. Hoffer, Luis B. Tovar‐y‐Romo, Nils‐Göran Larsson   +10 more
openalex   +2 more sources

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source