Results 211 to 220 of about 837,511 (259)

Penile Cancer Distant Metastasis or Primary Lung Cancer? Using Focused Genomic Profiling of Tumor and Germline Mutations With Next-Generation Sequencing for Clinical Decision-Making. [PDF]

Cancer Rep (Hoboken)
Moen CA, Nordanger IM, Karlsdóttir Á, Honoré A, Juliebø-Jones P, Blomberg SM, Haslerud TM, Aamelfot C, Salminen PR, Beisland C, Vetti HH, Costea DE, Berget E.   +12 more
europepmc   +1 more source

A Recurrent Tympanicum Paraganglioma With a SDHD Pathogenic Variant: Fourth Reported Case

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective The aim of this study is to describe a clinical case of a SDHD germline mutation associated tympanic paraganglioma (TPGL). Patients A female patient seen in the otology clinic at a tertiary care center with a diagnosis of tympanic paraganglioma and significant family history of head and neck paragangliomas.
Alex Z. Graboyes, Kevin Wong, Yonghong Huan, Jason A. Brant   +3 more
wiley   +1 more source

Depletion of loss-of-function germline mutations in centenarians reveals longevity genes. [PDF]

Nat Commun
Ying K, Castro JP, Shindyapina AV, Tyshkovskiy A, Moqri M, Goeminne LJE, Milman S, Zhang ZD, Barzilai N, Gladyshev VN.   +9 more
europepmc   +1 more source

RNAi‐based functional genomics tools for the beet leafhopper using microinjection and nanoparticle‐based topical spray

Insect Science, EarlyView.
• First demonstration of functional RNAi in the beet leafhopper, Neoaliturus tenellus, using both dsRNA microinjection and star polycation nanoparticle‐mediated topical spray delivery.•Microinjection achieved over 90% knockdown of Gus and Pum3, revealing gene‐specific fitness effects on survival and fecundity in beet leafhopper.•Nanoparticle‐mediated ...
Jinlong Han, Maria Paula Mejia Alonzo, Meihua Cui, Katherine O. Puffer, Anna M. Wolff, Garret M. Miyake, Oliver T. Neher, Vamsi J. Nalam, Punya Nachappa   +8 more
wiley   +1 more source

Identifying Novel Germline Mutations and Copy Number Variations in Patients With SCLC. [PDF]

JTO Clin Res Rep
Ul Haq S, Downs G, Zhan LJ, Schmid S, Patel D, Sacdalan D, Li JJN, Cheng D, Meti N, Philip V, Kim RH, Liu G, Bratman SV, Sabatini PJB, Lok BH.   +14 more
europepmc   +1 more source

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source

Increased TP53 somatic evolution in peritoneal washes of individuals with BRCA1 germline mutations. [PDF]

Gynecol Oncol
Tee XR, Hazard E, Latorre-Esteves E, Kohrn BF, Ghezelayagh TS, Fredrickson JU, Coombes C, Radke MR, Manhardt E, Katz R, Soong TR, Swisher EM, Norquist BM, Risques RA.   +13 more
europepmc   +1 more source

MSH6 germline mutations leading to Lynch syndrome-associated cholangiocarcinoma: a case report. [PDF]

Front Oncol
Zhang Z, Ma S, Li S, Chen Z, Song R, Wang Z.   +5 more
europepmc   +1 more source

Broader Familial Cancer Risk in Relatives of Testicular Cancer Patients: Insights From Two Mediterranean Populations

Andrology, EarlyView.
ABSTRACT Background Familial clustering of testicular germ cell tumour (TGCT) is well‐established, whereas the risk of non‐testicular cancer among relatives remains inconsistent across studies. Objective To evaluate the overall and site‐specific cancer risk among first‐degree relatives and grandparents of TGCT patients compared to cancer‐free controls.
Csilla Krausz, Chiara Abrardo, Viktoria Rosta, Daniel Moreno‐Mendoza, Luca Bressan, Matteo Vannucci, Rebecca Passerotti, Arianna Meacci, Ginevra Farnetani, Viola Bonini, Giovanni Corona, Maria Grazia Fino, Eduard Ruiz‐Castañé, Antoni Riera‐Escamilla   +13 more
wiley   +1 more source

Germline mutations in pediatric cancer cohort with mixed-ancestry Mexicans. [PDF]

Mol Genet Genomic Med
Alonso-Luna O, Mercado-Celis GE, Melendez-Zajgla J, Barquera R, Zapata-Tarres M, Juárez-Villegas LE, Mendoza-Caamal EC, Rey-Helo E, Borges-Yañez SA.   +8 more
europepmc   +1 more source