Results 21 to 30 of about 80,990 (260)
Frontiers in Public Health, 2021 The perception of feeling lonely is an influential factor in determining quality of life among aging adults. As the US Census Bureau projects that the number of Americans ages 65 and older will double by 2060, reducing loneliness is imperative.
Valerie K. Jones +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Portraits of Brazil: where do we stand in 2025? – Geriatrics and Gerontology [PDF]
Geriatrics, Gerontology and AgingGeriatrics and gerontology in Brazil have their roots in the 1950s, with the foundation of the Brazilian Society of Geriatrics in 1961, which incorporated gerontology in 1969.
Marco Túlio Gualberto Cintra +3 more
doaj +1 more source
Geriatric Care, 2021 e-Health technologies may potentially improve healthcare assistance for frail elderly subjects. However, despite the interest and potential benefits of the field, research highlighted that several challenges remain, such as scarce wide spreading of ...
Alberto Cella +12 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Imagining Possibilities: A Conversation with Dr. Aaron T. Seaman, President of AAGE
Anthropology & Aging, 2021 -
Brooke Jespersen
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Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
How is the Frequency of Volunteering Associated with the Well-Being of Older Adults?: A Mini Review
Archives of Gerontology and Geriatrics PlusVolunteering in the advancing years has received abundant attention amongst the ageing population. A mini review of past studies on the key concepts of volunteerism with regard to the research area on the well-being of OAs and the types of evidence ...
Karen Gan, M Ger +1 more
doaj +1 more source