Results 41 to 50 of about 284,233 (249)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Peso à cobrição e ganho de peso durante a gestação de cabras nativas, exóticas e mestiças no semi-árido Mating weight and weight gain during gestation of native, exotic and crossbred goats in the semi-arid

Revista Brasileira de Zootecnia, 2004
Avaliaram-se os efeitos de mês, ano, ordem de parto e tipo de parto sobre o peso à cobrição (PC) e o ganho de peso durante a gestação (GP), respectivamente, de 753 e 527 cabras nativas Canindés, 463 e 333 cabras exóticas Anglo-nubianas, 374 e 296 Alpinas,
Geovergue Rodrigues de Medeiros, Edgard Cavalcanti Pimenta Filho, Wandrick Hauss de Sousa, Evaneusa Alves de Brito   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Conocimientos sobre salud bucal y demanda de servicios estomatológicos en relación con la enfermedad periodontal en embarazadas Knowledge on oral health and demand of dental services in relation to the periodontal disease in pregnant women

Revista Cubana de Estomatología, 2008
OBJETIVOS: evaluar el nivel de conocimientos sobre salud bucal y su relación con la prevalencia y gravedad de la enfermedad periodontal, así como la demanda de servicios estomatológicos por parte de las embarazadas, determinar la prevalencia y gravedad ...
Caridad Almarales Sierra, Yuliette Llerandi Abril   +1 more
doaj  

Dietary Fiber Supplementation in Gestating Sow Diet Improved Fetal Growth and Placental Development and Function Through Serotonin Signaling Pathway

Frontiers in Veterinary Science, 2022
The experiment was conducted to investigate the effects of dietary fiber (DF) supplementation in gestation diet on fetal growth and placental development and function and explore the possible mechanism of DF improving sow reproductive performance.
Yang Li, Yang Li, Min Yang, Min Yang, Lijia Zhang, Zhengyu Mao, Yan Lin, Shengyu Xu, Zhengfeng Fang, Lianqiang Che, Bin Feng, Jian Li, Yong Zhuo, De Wu   +13 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Optimising neonatal services for very preterm births between 27+0 and 31+6 weeks gestation in England: the OPTI-PREM mixed-methods study

Health and Social Care Delivery Research
Aim To investigate, for preterm babies born between 27+0 and 31+6 weeks gestation in England, optimal place of birth and early care. Design Mixed methods. Setting National Health Service neonatal care, England.
Thillagavathie Pillay, Oliver Rivero-Arias, Natalie Armstrong, Sarah E Seaton, Miaoqing Yang, Victor L Banda, Kelvin Dawson, Abdul QT Ismail, Vasiliki Bountziouka, Caroline Cupit, Alexis Paton, Bradley N Manktelow, Elizabeth S Draper, Neena Modi, Helen E Campbell, Elaine M Boyle   +15 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Early Life Programming of Adipose Tissue Remodeling and Browning Capacity by Micronutrients and Bioactive Compounds as a Potential Anti-Obesity Strategy

Cells
The early stages of life, especially the period from conception to two years, are crucial for shaping metabolic health and the risk of obesity in adulthood.
M. Luisa Bonet, Joan Ribot, Juana Sánchez, Andreu Palou, Catalina Picó   +4 more
doaj   +1 more source