Results 61 to 70 of about 262,182 (357)

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels. [PDF]

, 2020
Changes in fetal DNA methylation (DNAm) of the leptin (LEP) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear.
Bouchard, Luigi, Breton, Edith, Cardenas, Andres, Fortin, Carol-Ann, Gagné-Ouellet, Valérie, Guérin, Renée, Hivert, Marie-France, Perron, Patrice, Thibeault, Kathrine   +8 more
core   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates [PDF]

, 2014
BB/H012494/1/ Biotechnology and Biological Sciences Research ...
Barg E, Bejamini Y, Chris Mathews, David J Williams, Graham A Hitman, Melissa C Smart, Robert Lowe, Sara L Hillman, Sarah Finer, Smyth GK, Vardhman K Rakyan   +10 more
core   +3 more sources

Identifying Key Questions and Challenges in Microchimerism Biology

Advanced Science, EarlyView.
This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua, Rachel C. Quilang, Katja Sallinger, Christina Athena Aktipis, Petra Arck, Diana W. Bianchi, Hyun‐Dong Chang, Henderson J. Cleaves II, Michael Eikmans, Heidi E. S. Fjeldstad, David Haig, Whitney E. Harrington, William Horsnell, Daniel P. Jacobsen, Mads Kamper‐Jørgensen, Sami B. Kanaan, Kiarash Khosrotehrani, Nathalie C. Lambert, Jane Lee Nelson, Maria B. Olsen, Tiffany D. Pan, Jelmer R. Prins, Frank A. Schildberg, Anne Cathrine Staff, Anders Ståhlberg, Ina A. Stelzer, Christopher Urbschat, Sing Sing Way, Melissa A. Wilson, Jody Ye, Thomas Kroneis, Amy M. Boddy   +31 more
wiley   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Birthweight and risk markers for type 2 diabetes and cardiovascular disease in childhood: the Child Heart and Health Study in England (CHASE). [PDF]

, 2015
AIMS/HYPOTHESIS: Lower birthweight (a marker of fetal undernutrition) is associated with higher risks of type 2 diabetes and cardiovascular disease (CVD) and could explain ethnic differences in these diseases. We examined associations between birthweight
A Bavdekar, A Lucas, Alicja R. Rudnicka, Angela S. Donin, AS Donin, AS Donin, B Park, BJ McNamara, C Li, C Thomas, Cathy M. McKay, CG Owen, Christopher G. Owen, Claire M. Nightingale, CM Law, CM Nightingale, CM Nightingale, CS Yajnik, DA Lawlor, Debbie A. Lawlor, Derek G. Cook, DJ Barker, DL Kuh, F Mzayek, GV Krishnaveni, I Shai, J West, JC Levy, Jennifer L. Bales, MC Franco, MR Skilton, Naveed Sattar, Office for National Statistics, P Fossati, Peter H. Whincup, PH Whincup, PH Whincup, PH Whincup, PH Whincup, PH Whincup, Phillip J. Steer, R Huxley, R Huxley, R Huxley, R Pfister, RS Bhopal, S Kodama, SH Wild, Sian L. Newton, SM Sayers, T Kaneshi, WB White, YK Tu   +52 more
core   +2 more sources

A Multicenter Collaborative Study on the Safety and Efficacy of Laparoscopic Appendectomy During Pregnancy

Annals of Gastroenterological Surgery, EarlyView.
Laparoscopic appendectomy (LA) during pregnancy was evaluated in a multicenter retrospective study in Japan. LA showed comparable maternal and fetal safety to open appendectomy (OA), supporting the feasibility and safety of LA in pregnant patients. ABSTRACT Aim Acute appendicitis in pregnant women requires accurate diagnosis and treatment because of ...
Katsuhiro Ogawa, Tomonori Akagi, Hidefumi Shiroshita, Hiroshi Yoshida, Masashi Miguchi, Ken Eto, Tetsuji Ohyama, Akiyoshi Kanazawa, Keiji Matsuda, Koya Hida, Seiichiro Yamamoto, Takeshi Naitoh, Masafumi Inomata, Japan Society of Laparoscopic Colorectal Surgery   +13 more
wiley   +1 more source

Adiponectin Deficiency Impairs Maternal Metabolic Adaptation to Pregnancy in Mice. [PDF]

, 2017
Hypoadiponectinemia has been widely observed in patients with gestational diabetes mellitus (GDM). To investigate the causal role of hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq-/- ) and wild-type (WT) mice were crossed to produce ...
Hay, William W, Lee, Samuel, Nguyen, Amanda, Qiao, Liping, Schaack, Jerome, Shao, Jianhua, Wattez, Jean-Sebastien   +6 more
core   +1 more source

Mortality Patterns and Phenotypic Clusters in Trisomy 13: A Population‐Based Study From Japan

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Trisomy 13, the third most common autosomal trisomy after trisomy 21 and trisomy 18, is associated with a significantly high infant mortality rate. However, large‐scale studies examining causes of death in trisomy 13 remain scarce. Therefore, we aimed to better understand the mortality patterns.
Narumi Kato, Naho Morisaki, Akinori Moriichi   +2 more
wiley   +1 more source