Results 31 to 40 of about 5,004,763 (240)

p21-activated kinase-1 promotes aggressive phenotype, cell proliferation, and invasion in gestational trophoblastic disease

, 2010
Gestational trophoblastic disease (GTD) includes hydatidiform mole (HM), which can develop persistent gestational trophoblastic neoplasia requiring chemotherapy; choriocarcinoma, which is a frankly malignant tumor; placental site trophoblastic tumor; and
Chan, DCW, Kong, DSH, Ho, JWK, Yeung, MCW, Ngan, HYS, Siu, MKY, Cheung, ANY, Zhang, H   +7 more
core   +1 more source

Monitoring complete hydatidiform molar pregnancies after normalisation of human chorionic gonadotrophin: national retrospective population study

BMJ Medicine
Objective To provide evidence for a reduced surveillance protocol to detect gestational trophoblastic neoplasia after normalisation of human chorionic gonadotrophin (hCG) levels following uterine evacuation of a complete hydatidiform mole.Design National
Nienke E van Trommel, Christianne A R Lok, Naveed Sarwar, Leonoor Coopmans, Michael J Seckl, Baljeet Kaur, Lina Salman, Brenna E Swift, Geoffrey Maher, Matthew Winter, Xianne Aguiar, Reece Caldwell, Kam Singh, Christopher Coyle, Edmund H Wilkes, Imran Jabbar, Julia E Palmer, Eshan Ghorani   +17 more
doaj   +1 more source

Gestational Trophoblastic Disease

, 2019
The diagnosis of gestational trophoblastic disease has witnessed revolutionary changes with improved availability of immunohistochemistry and genotyping as valuable adjuncts.
Wang, RW, Cheung, ANY
core   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Gestational trophoblastic disease [PDF]

, 2008
La enfermedad trofoblástica gestacional (ETG) comprende un grupo de lesiones trofoblásticas benignas, anormalidades en la formación de la placenta como son las molas hidatidiformes (MH) completas y parciales, y la neoplasia trofoblástica gestacional ...
Oróstegui Correa, Simón, Galindo Navas, Lina María, Arenas Rueda, Yuli Andrea   +2 more
core  

Overexpression of the parkinson disease protein DJ-1 and its regulator PTEN in gestational trophoblastic disease

, 2010
DJ-1 is found to be important in human neurodegenerative diseases and cancers by regulating oxidative damage and apoptosis. DJ-1 is also a regulator of PTEN, a frequently mutated tumor suppressor gene in cancers.
Hextan Yuen-Sheung Ngan, Victor Chun-Yin Mak, Hui-Juan Zhang, Zhang, HJ, Mak, VCY, Ngan, HYS, Annie Nga-Yin Cheung, Siu, MKY, Li-Li Jiang, Jiang, LL, Michelle Kwan-Yee Siu, Cheung, ANY   +11 more
core   +1 more source

Uterine Rupture Due to Invasive Metastatic Gestational Trophoblastic Neoplasm

Western Journal of Emergency Medicine, 2013
While complete molar pregnancies are rare, they are wrought with a host of potential complications to include invasive gestational trophoblastic neoplasia.
David I Bruner, Amy M Pritchard, Jonathan Clarke   +2 more
doaj   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Gestational Trophoblastic Disease with Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ?

, 2016
Gestational trophoblastic neoplasms (GTN) originate from placental tissue and usually metastasizes because of its propensity for early vascular invasion. Intracranial metastases are relatively uncommon.
Serkan Uysal, Metin Demircin, Ulaş Kumbasar, Sevgen Önder, Tuba Kılıçer Şahinoğlu   +4 more
core   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source