Results 41 to 50 of about 7,868 (215)

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Comparing and Evaluating Five-Day Chemotherapy Agents Actinomycin D and Methotrexate in Low-Risk Post-Molar Gestational Trophoblastic Neoplasia: A Retrospective Analysis

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Low-risk post-molar gestational trophoblastic neoplasia is sensitive to chemotherapy, but there is no consensus regarding the best treatment regimen for low-risk post-molar gestational trophoblastic neoplasia.
Juan Xu, Xinmei Wang, Pengpeng Qu
doaj   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Is Doppler ultrasound useful for evaluating gestational trophoblastic disease?

Clinics
Doppler ultrasound is a non-invasive method for evaluating vascularization and is widely used in clinical practice. Gestational trophoblastic neoplasia includes a group of highly vascularized malignancies derived from placental cells.
Lawrence H. Lin, Lisandra S. Bernardes, Eliane A. Hase, Koji Fushida, Rossana P.V. Francisco   +4 more
doaj   +1 more source

Mirror Syndrome (Ballantyne Syndrome): Prenatal Diagnosis, Pathophysiology, and the Role of Fetal Therapy—A Narrative Review

Prenatal Diagnosis, EarlyView.
ABSTRACT Mirror syndrome is a rare maternal–fetal condition associated with fetal hydrops and a high risk of adverse maternal and fetal perinatal outcomes. Its diagnosis is challenging due to the lack of standardized diagnostic criteria and its clinical and biochemical overlap with preeclampsia.
Riccardo Tudisco, Pauline Latapie, Anita Romiti, Alexandra Benachi, Maelig Abgral, Alexandre J. Vivanti   +5 more
wiley   +1 more source

Gestational Trophoblastic Disease: A Multimodality Imaging Approach with Impact on Diagnosis and Management

Radiology Research and Practice, 2014
Gestational trophoblastic disease is a condition of uncertain etiology, comprised of hydatiform mole (complete and partial), invasive mole, choriocarcinoma, and placental site trophoblastic tumor.
Sunita Dhanda, Subhash Ramani, Meenkashi Thakur   +2 more
doaj   +1 more source

Placental site trophoblastic tumor

Frontiers in Surgery, 2014
Trophoblastic tumors of placental site (PSTT) are rare. They represent a rare form of gestational trophoblastic disease. (GTD). They occur mainly in women who have a history of miscarriage, termination of pregnancy, or even a normal or pathological ...
Jean eBouquet De Jolinière
doaj   +1 more source

Downregulation of the gli transcription factors regulator Kif7 facilitates cell survival and migration of choriocarcinoma cells. [PDF]

PLoS ONE, 2014
The kinesin protein Kif7 has been recognized as an integral component of hedgehog signalling. Aberrant activation of hedgehog signalling has been implicated in many human solid tumours.
Joanna Ho, Yanan Du, Oscar Gee-Wan Wong, Michelle K Y Siu, Karen K L Chan, Annie N Y Cheung   +5 more
doaj   +1 more source

MR“I”: An “eye” for the preoperative diagnosis of ectopic molar pregnancy, a case report

Journal of Family Medicine and Primary Care, 2023
Hydatidiform mole (complete and partial), invasive mole, choriocarcinoma, placental site trophoblastic disease, and epithelioid trophoblastic tumour constitute the spectrum of benign and malignant gestational trophoblastic disease[1] Invasive mole ...
Sujith Rajashekar Swamy, Meghana Rajashekara Swamy, H. Samanvitha, Sara Elsayed   +3 more
doaj   +1 more source

Uterus‐preserving surgery for placenta accreta spectrum: An expert, illustrated review of techniques and its outcomes

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Uterus‐preserving strategies for PAS include myometrial resection and leaving placenta in situ, differing in surgical principles, complications, and follow‐up. Myometrial resection offers definitive treatment with lower rates of delayed morbidity, while leaving the placenta in situ minimizes surgical risk but is associated with prolonged follow‐up ...
Pedro Viana Pinto, Albaro José Nieto‐Calvache, Rafael José Vieira, Abdalla Mousa, Hooman Soleymani majd, Rozi Aditya Aryananda, José Miguel Palacios‐Jaraquemada   +6 more
wiley   +1 more source