Results 111 to 120 of about 135,716 (291)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
INTERFACE DESIGN OF AN INTELLIGENT INTERACTIVE LEARNING SYSTEM
Scientific Journal of Astana IT UniversityThis study presents the design, implementation, and evaluation of an Intelligent Interactive Learning System that employs multimodal interaction to improve the adaptability, accessibility, and engagement of digital education.
Aru Ukenova +3 more
doaj +1 more source
, 2013 Can our gestures help us think, and, if so, how? Previous work suggests that they can. Here, students, alone in a room, studied descriptions of environments for later tests of knowledge. The majority of participants spontaneously gestured while reading the descriptions, and most of those also gestured while answering true-false questions.
Jamalian, Azadeh +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Investigating the Relationship Among Communicative Gestures and Words in Tamil-speaking Children With Down Syndrome [PDF]
Iranian Rehabilitation JournalObjectives: Gestural usage is one of the earliest signs of intentional communication abilities. In children with down syndrome (DS), one of the most severely compromised areas of functioning is language.
Monish V +2 more
doaj
Virtual WorldsAs traffic automation grows, research into communication between automated vehicles (AVs) and pedestrians is increasing. Since communication is particularly challenging for persons with intellectual disability (PID), we investigated which gestures are ...
Mathias Haimerl +4 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
, 2010 On occasion, one can observe a whole orchestra section moving and playing in unison. In such an instance, all violinists play the melody using the same type of bowing movements and lean forward in unison at a given time during a specific passage in the ...
Rasamimanana, N. +6 more
core +1 more source
Embodiment of infinity in mathematics
Frontiers in PsychologyIn this article, we discuss the embodiment of infinity as one of fundamental concepts in mathematics. In contrast to the embodiment of many other mathematical concepts, the embodiment of infinity is an endless dynamic process.
Omid Khatin-Zadeh +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source