Results 121 to 130 of about 241,561 (365)

Grounding the Simulation of Iconic Gestures in Gesture Typology

open access: yes, 2011
Bergmann K, Kopp S, Rieser H. Grounding the Simulation of Iconic Gestures in Gesture Typology. In: Efthimiou E, Kouroupetroglou G, eds. Proceedings of the 9th International Gesture Workshop: Gestures in Embodied Communication and Human-Computer ...
Kopp, Stefan ; https://orcid.org/   +4 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

A Taxonomy of Gestures in Human Computer Interactions

open access: yes, 2005
We present a survey and taxonomy of gesture-based computer interactions motivated by a literature review of over 40 years of gesture based interactions.
M. C. Schraefel   +3 more
core  

Res gestae and/or gestures? Philosophical-educational notes on a(n alleged?) paradigm shift

open access: yes, 2021
After outlining his general theory of gestures as an “interface theory” synthesizing different disciplines, Vilém Flusser (1994) portrays a complex regime of relationships between a general theory of gestures and the philosophy of history.
Stefano Oliverio
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

The language of gestures in some of El Greco's altarpieces [PDF]

open access: yes
This study explores El Greco's language of gestures. The first part will explain the preconditions for the general development towards rhetorical gestures and draw parallels with El Greco's artistic development in the sphere of gestures.
Lühr, Berit
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Regulating Dialogue With Gestures---Towards an Empirically Grounded Simulation with Conversational Agents

open access: yes, 2011
Bergmann K, Rieser H, Kopp S. Regulating Dialogue With Gestures---Towards an Empirically Grounded Simulation with Conversational Agents. In: Chai JY, Moore JD, Passonneau RJ, Traum DR, eds. Proceedings of the SIGdial 2011 Conference.
Traum, D.R.   +6 more
core  

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