Results 131 to 140 of about 241,561 (365)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Emblems: Meaning at the interface of language and gesture

Glossa
Emblems—the THUMBS UP, the HEAD SHAKE, the PEACE SIGN, the SHHH—are communicative gestures that have a conventional form and conventional meaning within a particular community.
Kensy Cooperrider, Lauren Gawne
doaj   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Data-based analysis of speech and gesture: the Bielefeld Speech and Gesture Alignment corpus (SaGA) and its applications

, 2013
Lücking A, Bergmann K, Hahn F, Kopp S, Rieser H. Data-based analysis of speech and gesture: the Bielefeld Speech and Gesture Alignment corpus (SaGA) and its applications. Journal on Multimodal User Interfaces. 2013;7(1-2):5-18.Communicating face-to-face,
Hahn, Florian, Florian Hahn, Kopp, Stefan ; https://orcid.org/, Lücking, Andy, Hannes Rieser, Bergmann, Kirsten, Stefan Kopp, Kirsten Bergman, Rieser, Hannes, Andy Lücking   +9 more
core   +1 more source

Two hands and a tale: When gestures benefit adult narrative comprehension

, 2020
It is well established that observing and producing gesture by a learner can enhance comprehension of verbal messages, including narratives. What is less well understood, however, is under which conditions gestures benefit comprehension most.
Dargue, Nicole, Sweller, Naomi
core   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Combining gestures and vocalizations to imitate sounds

, 2015
International audienceCommunicating about sounds is a difficult task without a technical language, and naïve speakers often rely on different kinds of non-linguistic vocalizations and body gestures (Lemaitre et al. 2014).
Frédéric Voisin, Frédéric Bevilacqua, Voisin, Frédéric, Jules Françoise, Guillaume Lemaitre, Lemaitre, Guillaume,, Bevilacqua, Frédéric, Lemaitre, Guillaume, Susini, Patrick, Françoise, Jules, Hugo Scurto, Scurto, Hugo, Patrick Susini   +12 more
core   +1 more source

Prediction Analysis of Greeting Gestures Based on Recurrent Neural Networks

JOIV: International Journal on Informatics Visualization
Human activity recognition, such as rehabilitation, sports, human behavior, etc., is developing rapidly. A Recurrent Neural Network (RNN) is a practical approach to human activity recognition research and sequential data.
Angga Wibowo, - Kurnianingsih, Eri Sato-Shimokawara   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Landscape Gestures

, 2019
Our Landscape Gestures started when we bought an abandoned piece of rural land in 2009. Inspired by the concept of Garden in Movement of Gilles Clement, ecological conservation practices and Landscape Art, we started a process of experimentation in ...
Guibert, E.
core