Results 181 to 190 of about 127,947 (249)

Machine learning-based multi-transcriptomic integration highlights GFAP as a core biomarker in Alzheimer's disease [PDF]

Qi Zhang, Jialing Xiao, Zice Yan, Zhen Tang   +3 more
openalex   +1 more source

KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons

Cytoskeleton, EarlyView.
ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung, J. Sidhu, A. Hsieh, Y. Ma, J. Liu, M. A. Silverman   +5 more
wiley   +1 more source

Circulating blood biomarkers after traumatic brain injury: A subanalysis of the biperiden phase III randomized, double‐blind clinical trial (NCT01048138)

Epileptic Disorders, EarlyView.
Abstract Objective Traumatic brain injury (TBI) is a leading cause of acquired epilepsy, death, and long‐term disability, yet reliable biomarkers to predict chronic sequelae such as post‐traumatic epilepsy (PTE) remain limited. We evaluated the associations between circulating blood biomarkers of neuronal, glial, and synaptic injury and the subsequent ...
Michele Longoni Calió, Maira Licia Foresti, Luis Eduardo Santos, Amanda Cristina Mosini, Clivandir Severino Silva, Clara Pompeu, Juliana Willers, Thyago Leal Calvo, Almir Ferreira de Andrade, Saul Almeida da Silva, Eliana Garzon, Luiz Eugênio Mello   +11 more
wiley   +1 more source

4-Methylumbelliferone Restores Age-Related Changes in Perineuronal Nets, Memory, and Neuroinflammation. [PDF]

Glia
Cimpean A, Mizerakova J, Martinez-Varea N, Marekova D, Machova Urdzikova L, Fawcett JW, Jendelova P, Kwok JCF.   +7 more
europepmc   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Vergleich der Mengen der leichten Kette des Neurofilaments (NfL) und des sauren Gliafaserproteins (GFAP) im Blut von Patienten mit asymptomatischen Stenosen der Aa. carotides internae für die Evaluation von NfL und GFAP als Biomarker

Cleopatra Papasimos
openalex   +1 more source

GFAP upregulation by astrocytes attenuates tau neurofibrillary tangle pathology in a mouse model of tauopathy

Clara Muñoz‐Castro, Molly A Healey, Ayush Noori, Methasit Jaisa-aad, Paula Gómez-Méndez, Rojashree Jayakumar, Srinija Alla, Zane D. Kashlan, Zhanyun Fan, Eric F. Zaniewski, Sambhavi Animesh, Robert Tyler Morris, María Calvo-Rodríguez, Eloïse Hudry, Sudeshna Das, Wilhelm Haas, Bradley T. Hyman, Alberto Serrano‐Pozo   +17 more
openalex   +1 more source

Temperature homeostasis disruption and hypothalamic alterations in experimental drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Objective Elevated body temperature may increase seizure risk, yet the relationship between thermoregulation and seizures, as well as the underlying mechanisms, remains poorly understood. We investigated whether thermoregulatory control is altered in experimental temporal lobe epilepsy (TLE), as such impairment could reduce the ability of ...
Rossella Di Sapia, Akash Bera, Omar Mamad, James D. Mills, Benjamin Villasana‐Salazar, Giada Lavigna, Edoardo Micotti, Manuela Conticello, Asmin Alam, Roberto Chiesa, Francesca Pagani, Roberta Frapolli, Angelo M. Lavecchia, Christodoulos Xinaris, Eleonora Aronica, Andre Altmann, Teresa Ravizza, Sanjay M. Sisodiya, David C. Henshall, Annamaria Vezzani   +19 more
wiley   +1 more source

Biomarkers of brain injury in foals with neonatal maladjustment syndrome. [PDF]

J Vet Intern Med
Perez Quesada J, Coley K, Wong D, Browne N, Albrecht M, Dembek K.   +5 more
europepmc   +1 more source

Heterogeneity of GFAP Expression in Alzheimer’s Disease: A Perspective from the Vascular-Inflammation Axis

Yichen Chao, Yongchang Diwu
openalex   +2 more sources