Results 191 to 200 of about 158,206 (306)

Emerging CSF and Serum Biomarkers in Multiple Sclerosis: Cytokines, MOG, GFAP, and Beyond. [PDF]

Neurol Neuroimmunol Neuroinflamm
Oechtering J, Schaedelin SA, Maleska Maceski A, Stein K, Genc N, Einsiedler M, Benkert P, Willemse E, Derfuss TJ, Fischer-Barnicol B, D'Souza M, Regeniter A, Hu W, Qureshi F, Finkener S, Mueller S, Hoepner R, Lalive PH, Pot C, Gobbi C, Zecca C, Roth P, Wiendl H, Lünemann JD, Kappos L, Granziera C, Leppert D, Kuhle J, as the Swiss MS Cohort Study.   +28 more
europepmc   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Foreign Body Response to Neuroimplantation: Machine Learning-Assisted Quantitative Analysis of Astrogliosis. [PDF]

Int J Mol Sci
Melnikova AA, Egorchev AA, Rosin AA, Nurullin LF, Lipachev NS, Vedischeva DS, Derzhavin DV, Perepechenov SS, Sukhodolova EA, Shabernev GV, Titova AA, Kiyamova RG, Kiyasov AP, Chickrin DE, Aganov AV, Samigullin DV, Popova IY, Paveliev M.   +17 more
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

Neuroglial markers of damage in autoimmune neurology. [PDF]

Ther Adv Neurol Disord
Dinoto A, Mariotto S.
europepmc   +1 more source

Abunmix enables the simple and robust multiplexed immunofluorescence imaging

VIEW, EarlyView.
Multiplexed fluorescence imaging is limited by bleed‐through signals arising from the use of antibodies derived from the same host species. Abunmix can separate signals from multiple antibodies generated from the same host species using a signal unmixing algorithm.
Woonggi La, Seoungbin Bae, Junyoung Seo, Hayeong Yu, Junmo Cho, Hyunwoo Kim, Hoyeon Nam, Seungjae Han, Euiin Yi, Eunsu Kim, Chan Kang, Hyejin Shin, Chang Woo Song, Young‐Gyu Yoon, Jae‐Byum Chang   +14 more
wiley   +1 more source

Diversity of cortical progenitors directs neuronal layer formation and regional glial patterning. [PDF]

Stem Cell Reports
Ojalvo-Sanz AC, Figueres-Oñate M, Barriola S, Pernia-Solanilla C, Sanchez-Gonzalez R, Delgado-García LM, López-Mascaraque L.   +6 more
europepmc   +1 more source

Space biomedicine‐oriented bioink and biomimetic blood‒brain barrier

VIEW, EarlyView.
Bioinks and bioprinting play a pivotal role in the successful delivery of cell models and the fabrication of tissue models for space biomedicine research. This study investigated the effects of hypergravity and vibration on two‐dimensional adherent cells and three‐dimensional embedded cells and provided methods for storing hybrid bioink and high ...
Ranran Yan, Ge Gao, YuJuan Li, YuLin Deng   +3 more
wiley   +1 more source

GFAP⁺ FOXF2⁺ ependymal cells promote blood-brain barrier repair via DLL4-NOTCH signaling after neural injury. [PDF]

Proc Natl Acad Sci U S A
Xie Q, Lu H, Wang X, Wu S, He Q, Yuan M, Zhang S, Hu L, Gong C, Cheng X, Fang Y, Meng Z, Wang Y, Lin S, Yang Q.   +14 more
europepmc   +1 more source