Results 221 to 230 of about 38,958 (244)
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Peptides, 2019
Ghrelin, a growth hormone-releasing peptide that was first discovered in the stomach of rats in 1999, is an endogenous ligand of growth hormone secretagogue receptor. Ghrelin exerts its potent growth hormone-releasing and orexigenic activities by binding to specific receptors in the brain.
Takeshi Tokudome +3 more
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Ghrelin, a growth hormone-releasing peptide that was first discovered in the stomach of rats in 1999, is an endogenous ligand of growth hormone secretagogue receptor. Ghrelin exerts its potent growth hormone-releasing and orexigenic activities by binding to specific receptors in the brain.
Takeshi Tokudome +3 more
openaire +3 more sources
2007
A consequence of gastrectomy is loss of bone mass. Several mechanisms have been proposed, such as malabsorption of vitamins and minerals. Additionally, a peptide hormone produced in the stomach has been shown to mediate a calcitropic effect on bone.
Patric J.D. Delhanty +4 more
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A consequence of gastrectomy is loss of bone mass. Several mechanisms have been proposed, such as malabsorption of vitamins and minerals. Additionally, a peptide hormone produced in the stomach has been shown to mediate a calcitropic effect on bone.
Patric J.D. Delhanty +4 more
openaire +3 more sources
BioFactors, 2013
AbstractGhrelin is a gut‐derived peptide hormone, first isolated from the stomach. Ghrelin was initially characterized as a growth hormone (GH) secretagogue, but it plays a more important role as a potent orexigen and modulator of whole‐body energy homeostasis. Ghrelin itself is closely regulated by metabolic status.
Johannes P.T.M. van Leeuwen +2 more
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AbstractGhrelin is a gut‐derived peptide hormone, first isolated from the stomach. Ghrelin was initially characterized as a growth hormone (GH) secretagogue, but it plays a more important role as a potent orexigen and modulator of whole‐body energy homeostasis. Ghrelin itself is closely regulated by metabolic status.
Johannes P.T.M. van Leeuwen +2 more
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Current Opinion in Clinical Nutrition & Metabolic Care, 2017
A compromised autophagy is associated with the onset of obesity, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular and neurodegenerative diseases. Our aim is to review the potential role of ghrelin, a gut hormone involved in energy homeostasis, in the regulation of autophagy.In the recent years, it has been demonstrated that autophagy ...
Amaia Rodríguez +2 more
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A compromised autophagy is associated with the onset of obesity, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular and neurodegenerative diseases. Our aim is to review the potential role of ghrelin, a gut hormone involved in energy homeostasis, in the regulation of autophagy.In the recent years, it has been demonstrated that autophagy ...
Amaia Rodríguez +2 more
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Metabolic Syndrome and Related Disorders, 2006
Ghrelin was discovered for its ability to bind the growth hormone secretagogue receptor (GHSR1a) and stimulate growth hormone release. However, much research conducted with this novel stomach hormone is focused on proposed roles for it to participate in regulating energy balance.
Mark L. Heiman, Derrick R. Witcher
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Ghrelin was discovered for its ability to bind the growth hormone secretagogue receptor (GHSR1a) and stimulate growth hormone release. However, much research conducted with this novel stomach hormone is focused on proposed roles for it to participate in regulating energy balance.
Mark L. Heiman, Derrick R. Witcher
openaire +3 more sources
Current Opinion in Lipidology, 2015
The increasing prevalence of metabolic syndrome and the consequent cardiovascular diseases has stimulated an active search for novel risk factors. The hormones regulating energy balance are of special interest as potential risk factor indicators of cardiovascular diseases.
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The increasing prevalence of metabolic syndrome and the consequent cardiovascular diseases has stimulated an active search for novel risk factors. The hormones regulating energy balance are of special interest as potential risk factor indicators of cardiovascular diseases.
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The role of ghrelin and ghrelin analogues in wasting disease
Current Opinion in Clinical Nutrition and Metabolic Care, 2008The purpose of this review is to summarize recent studies that investigated the role of ghrelin and ghrelin analogs in wasting conditions.Numerous studies have demonstrated potential beneficial effects exerted by ghrelin in a number of diseases associated with wasting.
Mayra Mayumi Kamiji, Akio Inui
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2016
Ghrelin (GHRL) was first discovered as a growth hormone secretagog secreted from the stomach, and showed a novel regulatory pathway for GH secretion. In addition to this, feeding-stimulatory activity is expected from the production site in the arcuate nuclei of the hypothalamus, and it is now recognized as the only hormone to stimulate food intake ...
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Ghrelin (GHRL) was first discovered as a growth hormone secretagog secreted from the stomach, and showed a novel regulatory pathway for GH secretion. In addition to this, feeding-stimulatory activity is expected from the production site in the arcuate nuclei of the hypothalamus, and it is now recognized as the only hormone to stimulate food intake ...
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Ghrelin and the Endocrine Pancreas
Endocrine, 2003Ghrelin is a 28-amino-acid peptide predominantly produced by the stomach, while substantially lower amounts derive from other tissues including the pancreas. It is a natural ligand of the GH secretagogue (GHS) receptor (GHS-R1a) and strongly stimulates GH secretion, but acylation in serine 3 is needed for its activity.
BROGLIO, Fabio +10 more
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From Ghrelin to Ghrelin's O-Acyl Transferase
2012The hormone ghrelin is a unique signaling peptide with powerful metabolic effects, mediated by its acylated forms. The acyl modification of ghrelin is unique in that it takes place via a susceptible ester linkage in the conserved serine-3 of ghrelin and is composed principally of octanoyl and, to lesser extent, decanoyl fatty acids.
John E. Hale +7 more
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