Results 201 to 210 of about 8,222 (228)

Ghrelin-GHSR system in the eye: local regulation and pathophysiological implications

, 2013
openaire   +2 more sources

Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice.

Endocrinology
Poelman R, Le May MV, Schéle E, Stoltenborg I, Dickson SL.   +4 more
europepmc   +1 more source

Significance of neuroendocrine systems and the gut-brain axis (GBA) in the regulation of obesity. [PDF]

PeerJ
Zhao H, Li Y, Cheng R, Wang Y, Ma L, Chen W.   +5 more
europepmc   +1 more source

Correction to: "Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I".

J Clin Endocrinol Metab
europepmc   +1 more source

Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity

Bioorganic & Medicinal Chemistry Letters, 2010
Piperazine-bisamide analogs were discovered as partial agonists of human growth hormone secretagogue receptor (GHSR) in a high throughput screen. The partial agonists were optimized for potency and converted into antagonists through structure-activity relationship (SAR) studies.
Ming, Yu, Mike, Lizarzaburu, Holger, Beckmann, Richard, Connors, Kang, Dai, Katrin, Haller, Cong, Li, Lingming, Liang, Michelle, Lindstrom, Ji, Ma, Alykhan, Motani, Malgorzata, Wanska, Alex, Zhang, Leping, Li, Julio C, Medina   +14 more
openaire   +3 more sources

The ghrelin receptor GHSR has two efficient agonists in an ancient fish species

, 2023
AbstractThe gastric peptide ghrelin and its receptor GHSR have important functions in energy metabolism. Recently, liver-expressed antimicrobial peptide 2 (LEAP2) was identified as an endogenous antagonist for GHSR. Ghrelin, LEAP2, and GHSR are ubiquitously present from fishes to mammals and are highly conserved in evolution.
Hao-Zheng Li, Ya-Fen Wang, Yong-Shan Zheng, Ya-Li Liu, Zeng-Guang Xu, Zhan-Yun Guo   +5 more
openaire   +2 more sources

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Therapeutic potential of GHSR-1A antagonism in alcohol dependence, a review

Life Sciences, 2022
Growth hormone secretagogue receptor type 1A (GHSR-1A) is a functional receptor of orexigenic peptide ghrelin and is highly expressed in mesolimbic dopaminergic systems that regulate incentive value of artificial reward in substance abuse. Interestingly, GHSR-1A has also shown ligand-independent constitutive activity.
Shreyasi Gupta, Sanchari Mukhopadhyay, Arkadeep Mitra   +2 more
openaire   +2 more sources