Results 211 to 220 of about 8,222 (228)

LEAP2 is a more conserved ligand than ghrelin for fish GHSRs

Biochimie, 2022
ABSTRACTRecently, liver-expressed antimicrobial peptide 2 (LEAP2) was identified as an endogenous competitive antagonist and an inverse agonist of the ghrelin receptor GHSR. However, its functions in lower vertebrates are not well understood. Our recent study demonstrated that both LEAP2 and ghrelin are functional towards a fish GHSR from Latimeria ...
Hao-Zheng Li, Xiao-Xia Shao, Ya-Fen Wang, Ya-Li Liu, Zeng-Guang Xu, Zhan-Yun Guo   +5 more
openaire   +2 more sources

Adenosine is not a direct GHSR agonist – artificial cross‐talk between GHSR and adenosine receptor pathways

Acta Physiologica, 2007
AbstractAim: To assess if adenosine is a direct growth hormone secretagogue receptor (GHSR) agonist by investigating the mechanism behind adenosine induced calcium release in human embryonic kidney 293s (HEK) cells expressing GHSR.Methods: Calcium mobilization, cyclic adenosine monophosphate (cAMP) and IP3experiments were performed using HEK cells ...
N-O, Hermansson, D G A, Morgan, T, Drmota, N, Larsson   +3 more
openaire   +2 more sources

The new mechanism of Ghrelin/GHSR-1a on autophagy regulation

Peptides, 2020
Autophagy is associated with several diseases. In recent years, accumulating evidence has suggested that ghrelin pathway exerts a protective effect by regulating autophagy. This review aims to assess the potential role and use of ghrelin as a new treatment for obesity, cardiovascular diseases, nonalcoholic fatty liver disease (NFALD), neurodegenerative
Ming-Jie, Yuan, Tao, Wang
openaire   +2 more sources

Molecular cloning and analysis of the ghrelin/GHSR system in Xenopus tropicalis

General and Comparative Endocrinology, 2023
Ghrelin is a gut-derived peptide with several physiological functions, including feeding, gastrointestinal motility, and hormonal secretion. Recently, a host defense peptide, liver-expressed antimicrobial peptide-2 (LEAP2), was reported as an endogenous antagonist of growth hormone secretagogue receptor (GHS-R).
Reiko, Wada, Shota, Takemi, Mio, Matsumoto, Mio, Iijima, Takafumi, Sakai, Ichiro, Sakata   +5 more
openaire   +2 more sources

Dopamine D2 receptor; ghrelin receptor (GHSR) [PDF]

Science-Business eXchange, 2012
openaire   +2 more sources

Investigation of GHSR and GHRL Methylation in Colorectal Cancer

Epigenomics, 2018
To investigate GHSR and GHRL methylation in 73 pairs of colorectal cancer (CRC) tissues and healthy adjacent mucosa.Methylation was assessed with methylation-sensitive high-resolution melting.GHSR was significantly hypermethylated in CRC tissues than in healthy mucosa (p 
Coppedè, Fabio, Stoccoro, Andrea, Lazzarotti, Alessandro, Spisni, Roberto, Migliore, Lucia   +4 more
openaire   +3 more sources

Investigation of GHSR methylation levels in thymomas from patients with Myasthenia Gravis

Gene, 2020
Hypermethylation of the growth hormone secretagogue receptor gene (GHSR) is increasingly observed in human cancers, suggesting that it could represent a pan-cancer biomarker of clinical interest. However, little is still known concerning GHSR methylation levels in thymic epithelial tumors, and particularly in thymomas from patients with Myasthenia ...
Coppede F., Stoccoro A., Nicoli V., Gallo R., De Rosa A., Guida M., Maestri M., Lucchi M., Ricciardi R., Migliore L.   +9 more
openaire   +3 more sources

Diagnostic values of GHSR DNA methylation pattern in breast cancer

Breast Cancer Research and Treatment, 2012
DNA methylation patterns have been recognised as cancer-specific markers with high potential for clinical applications. We aimed at identifying methylation variations that differentiate between breast cancers and other breast tissue entities to establish a signature for diagnosis.
Sandeep Kumar, Botla, Amin Moghaddas, Gholami, Mahdi, Malekpour, Evgeny A, Moskalev, Mahdi, Fallah, Pouria, Jandaghi, Ali, Aghajani, Irina S, Bondar, Ramesh, Omranipour, Fatemeh, Malekpour, Abbas, Mohajeri, Azin Jahangiri, Babadi, Özgür, Sahin, Vladimir V, Bubnov, Hossein, Najmabadi, Jörg D, Hoheisel, Yasser, Riazalhosseini   +16 more
openaire   +2 more sources

Associations of GHSR gene polymorphisms with chicken growth and carcass traits

Molecular Biology Reports, 2009
Ghrelin receptor (GHSR), or growth hormone secretagogue receptor, modulates many physiological effects by binding to its ligand and therefore is a candidate gene for chicken production performance. In this study, five polymorphisms (four SNP and a 'GGTACA' indel) of GHSR gene were genotyped in a F(2) full sib chicken population to investigate their ...
Meixia, Fang, Qinghua, Nie, Chenlong, Luo, Dexiang, Zhang, Xiquan, Zhang   +4 more
openaire   +2 more sources

The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice

Neuropharmacology, 2019
Ghrelin is an orexigenic hormone that also plays an important role in mood disorders. Our previous studies demonstrated that ghrelin administration could protect against depression-like behaviors of chronic unpredictable mild stress (CUMS) in rodents. However, the mechanism related to the effect of ghrelin on CUMS mice has yet to be revealed.
Hui-Jie, Huang, Xiao-Rong, Chen, Qiu-Qin, Han, Jing, Wang, Adam, Pilot, Rui, Yu, Qiong, Liu, Bing, Li, Gen-Cheng, Wu, Yan-Qing, Wang, Jin, Yu   +10 more
openaire   +2 more sources