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Immune Checkpoint Inhibitors and Cardiovascular Adverse Events
ESC Heart Failure, Volume 12, Issue 4, Page 2404-2416, August 2025.Abstract
In the last years, we assisted to a tremendous increase in therapeutic options for the management of cancers, with immunotherapy at the forefront of this innovation. Immune checkpoint inhibitors (ICIs) have been developed to enhance the activity of the immune system against cancer cells (1) and the number of approvals for ICIs has rapidly ...Maria Luisa De Perna, Elia Rigamonti, Raffaele Zannoni, Vittoria Espeli, Giorgio Moschovitis +4 morewiley +1 more sourceRisk loci involved in giant cell arteritis susceptibility: a genome-wide association study [PDF]
Background: Giant cell arteritis is an age-related vasculitis that mainly affects the aorta and its branches in individuals aged 50 years and older. Current options for diagnosis and treatment are scarce, highlighting the need to better understand its ...Abercrombie D., Abioye T., Abusalameh M., Al-Saffar Z. S., Allen N., Armstrong L., Atchia I., Barclay C., Bartholomew J., Bejarano V., Beretta L., Berger C. T., Bhagat S., Bhargava A., Bhat S., Bird G., Black K., Blockmans D., Borrego-Yaniz G., Boyles L., Brock J., Brouwer E., Brown P. C., Buckley M., Bukhari M., Burnett R., Callejas J. L., Calver J., Camden-Woodley T., Caminal-Montero L., Carette S., Castaneda S., Castelino M., Chung S., Cid M. C., Cimmino M. A., Collins D., Cooper R., Corbera-Bellalta M., Cruz C., Cuthbertson D., Daikeler T., Dale J., Dasgupta B., Davis D., Dawson J., de Guzman R., De Lord D., de Miguel E., Deery J., Defever E., Diamantopoulos A. P., Diaz-Lopez J. B., Dmello A., Dooks E., Douglas V., Duffy S., Durrant D., Dyche L., Eapen S., Elliott K., Emmi G., Emsley H., Farley R., Fleming V., Fletcher A., Forbess L. J., Fothergill L., Francis R., Frankland H., Fyfe R., Garcia-Villanueva M. J., George E., Gewurz-Singer O., Gomez-Vaquero C., Gonzalez-Gay M. A., Gordon E., Govoni M., Graham D., Graver C., Green L., Green M., Green M., Gregory L., Guijarro-Rojas M., Gumus S., Gunter E., Guthrie L. B., Hall A., Hammonds F., Hare M., Haroche J., Harrison A., Hawkins E., Hawkins H., Hazelton T., Hernandez R., Hernandez-Rodriguez J., Hettiarachchi C., Hewitson N., Hidalgo-Conde A., Hinchcliffe-Hume H., Hoffman G. S., Hollas C., Holle J., Hollinshead K., Hope S., Horton S., Htut E. P., Hughes A., Hughes R., Hunter K., Hussein A., Hutchinson D., Iles M., Isaacs J., Jarrett S., Jefferey R., Jeffrey H., Jilani A., John L., John S., Johnston P., Johson L., Jordan N., Kamanth S., Kapur D., Kay D., Kennedy J., Kerick M., Khalidi N., Khan A., Khurshid M., King J., Kirkwood S., Klapa S., Koening C. L., Kouroupis M., Labao J., Lamprecht P., Lane S., Langford C. A., Lanyon P., Lawson C., Laxminarayan R., Levy S., Lewszuk A., Li C., Lloyd M., Lorenzi A., Luqmani R., Mackay K., Mackie S. L., Madrid-Paredes A., Magliano M., Maher L., Mahr A., Makkuni D., Maksimowicz-McKinnon K. M., Mallinson J., Manzo K., Mari-Alfonso B., Marianayagam T., Marks J., Marquez A., Martin J., Martin M., Martinez-Berriochoa A., Martinez-Taboada V. M., Martinez-Zapico A., Masunda B., McAlear C. A., McHugh N., McLintock G., Menon A., Merkel P. A., Mestre-Torres J., Miranda-Filloy J. A., Moar K., Molberg O., Mollan S., Molloy E. S., Monach P. A., Monfort J., Moots R., Morado I. C., Moreland L. W., Morgan A. W., Morris V., Mouthon L., Mukhtyar C., Mushapaidzi T., Nandagudi A., Nandi P., Narvaez J., Neale T., Neumann T., Nunag A., Nyathi S., O'Connor S., O'Kane D., O'Sullivan E., O'Sunmboye K., Ogor J., Ortego-Centeno N., Ortiz-Fernandez L., Pagnoux C., Papo T., Parker B., Patel Y., Pearce K., Pegler S., Perez-Conesa M., Perry M., Peters J., Pothecary C., Pradere M. -J., Price L., Prieto-Gonzalez S., Pugmire S., Pugnet G., Rahan R., Raj S., Ramentol-Sintas M., Ramos A., Raya E., Record J., Redome J., Reynolds G., Rhys-Dillon C., Ridings D., Rios-Fenandez R., Rivett A., Robson J., Rowlands J., Royon A., Rushby N., Sadik H., Salvarani C., Sanchez-Martin J., Sanghera B., Sayan A., Schonau V., Seo P., Seward A., Sharma P., Singh A., Skeoch S., Slack L., Smithson G., Sofat N., Solans R., Sopena B., Sorensen L., Specks U., Spiera R. F., Sreih A., Stafford S., Stevens R., Stockham L., Sultan S., Tait M., Thankachen M., Thomas E., Thompson A., Thompson C., Tio L., Toms T., Tomson L., Toomey J., Unzurrunzaga A., Vadivelu S., Vaglio A., van Sleen Y., Voskuyl A., Walker C., Walsh M., Warner E., Warrington K. J., Weisman M., Welch G., Whitwell I., Wilcox L., Wilde C., Wilhelmsen E., Williams C., Williams E., Winter L., Witte T., Wordsworth O., Wright S., Ye C. -S., Ytterberg S. +292 morecore +1 more sourceDefinitions and reliability assessment of elementary ultrasound lesions in giant cell arteritis: a study from the OMERACT Large Vessel Vasculitis Ultrasound Working Group
RMD Open, 2018 Objectives To define the elementary ultrasound (US) lesions in giant cell arteritis (GCA) and to evaluate the reliability of the assessment of US lesions according to these definitions in a web-based reliability exercise. Methods Potential definitions of S. Chrysidis, C. Duftner, C. Dejaco, V. Schäfer, S. Ramiro, G. Carrara, C. Scirè, A. Hočevar, A. Diamantopoulos, A. Iagnocco, C. Mukhtyar, C. Ponte, E. Naredo, E. de Miguel, G. Bruyn, K. Warrington, L. Terslev, M. Milchert, M. D’Agostino, M. Koster, N. Rastalsky, P. Hanova, P. Macchioni, T. Kermani, T. Lorenzen, U. M. Døhn, U. Fredberg, W. Hartung, B. Dasgupta, W. Schmidt +29 moresemanticscholar +1 more sourceInfluence of the IL17A locus in giant cell arteritis susceptibility [PDF]
, 2017 Objective: Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its ...Beretta, Lorenzo, Blanco, Ricardo, Boiardi, Luigi, Braun, Niko, Caminal Montero, L., Castañeda, Santos, Cid Xutglà, M. Cinta, Fernández-Contreras, M. E., García-Villanueva, María Jesús, González-Gay, Miguel A., Gómez Vaquero, Carmen, Hernández Rodríguez, José, Latus, J., Martín, Javier, Martínez Taboada, Víctor Manuel, Miguel, Eugenio de, Molberg, O., Monfort, Jordi, Moosig, Frank, Morado, Inmaculada C., Márquez, Ana, Narváez García, Francisco Javier, Ortego Centeno, Norberto, Palm, Oyvind, Pazzola, Giulia, Ramentol, Marc, Salvarani, Carlo, Santaniello, Alessandro, Solans, Roser, Sopeña, Bernardo, Spanish GCA Consortium, Witte, Torsten +31 morecore +1 more sourceGlucocorticoid Dosages and Acute‐Phase Reactant Levels at Giant Cell Arteritis Flare in a Randomized Trial of Tocilizumab
Arthritis & Rheumatology, 2019 This study was undertaken to evaluate glucocorticoid dosages and serologic findings in patients with giant cell arteritis (GCA) flares.J. Stone, K. Tuckwell, S. Dimonaco, M. Klearman, M. Aringer, D. Blockmans, E. Brouwer, M. Cid, B. Dasgupta, J. Rech, C. Salvarani, H. Schulze-Koops, G. Schett, R. Spiera, S. Unizony, N. Collinson +15 moresemanticscholar +1 more sourceA new era for giant cell arteritis
Eye, 2019 The landscape of the investigation and management of giant cell arteritis (GCA) is advancing. In this review we will outline the recent advances by searching the current English literature for relevant articles using key words of giant cell arteritis ...H. Lyons, V. Quick, A. Sinclair, S. Nagaraju, S. Mollan +4 moresemanticscholar +1 more source
