Results 61 to 70 of about 104,517 (284)

Maintenance of Remission After Tocilizumab Withdrawal in Patients With Glucocorticoid‐Dependent Polymyalgia Rheumatica

Arthritis &Rheumatology, EarlyView.
Objective The SEMAPHORE trial evaluated the efficacy and safety of tocilizumab (TCZ) treatment in patients with glucocorticoid (GC)‐dependent polymyalgia rheumatica (PMR). TCZ reduced GC dose and disease activity at week 24. This study aimed to assess relapse rates after stopping TCZ treatment in patients achieving remission at week 24.
Baptiste Chevet, Aghiles Souki, Emmanuel Nowak, Guillermo Carvajal‐Alegria, Emmanuelle Dernis, Christophe Richez, Marie‐Elise Truchetet, Daniel Wendling, Eric Toussirot, Aleth Perdriger, Jacques‐Eric Gottenberg, Renaud Felten, Bruno Fautrel, Anne Lohse, Laurent Chiche, Pascal Hilliquin, Catherine Le Henaff, Benjamin Dervieux, Guillaume Direz, Isabelle Chary‐Valckenaere, Divi Cornec, Dewi Guellec, Thierry Marhadour, Alain Saraux, Valérie Devauchelle‐Pensec   +24 more
wiley   +1 more source

ICAM G241A polymorphism and soluble ICAM-1 serum levels: Evidence for an active immune process in schizophrenia [PDF]

, 2005
Objectives: We have previously reported reduced serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in schizophrenic patients. A single-nucleotide polymorphism ( SNP) of the ICAM-1 gene was described at position 241.
Ackenheil, Manfred, Kronig, H., Möller, Hans-Jürgen, Müller, Norbert, Riedel, M., Schwarz, Markus J., Strassnig, M.   +6 more
core   +1 more source

Giant cell arteritis: A case report and review of literature

Radiology Case Reports, 2021
Giant cell arteritis, the most common form of vasculitis in the elderly, is characterized by granulomatous inflammation of arteries, which can lead to serious, life-threatening conditions including aortic aneurysms, ruptures, and dissections as well as ...
Matthew A. Crain, BS, Dhairya A. Lakhani, MD, Lana Winkler, MD, Ayodele Adelanwa, MD, Cathy Kim, MD   +4 more
doaj  

Late‐Onset Spondylarthritis Presenting as Glucocorticoid‐Resistant Polymyalgia Rheumatica: A hitherto underappreciated entity where TNF or IL‐17 Blockade may have a Therapeutic Role

Arthritis &Rheumatology, Accepted Article.
Background Polymyalgia rheumatica (PMR) is an age‐related inflammatory disease with shoulder‐hip girdle involvement. Magnetic resonance imaging (MRI) reveals extracapsular/entheseal soft tissue involvements in both PMR and spondyloarthritis (SpA) with sacroiliac joint and peri‐entheseal spinal bone marrow oedema (BMO) being characteristic of SpA ...
Kerem Abacar, Gabriele De Marco, Jake Weddell, Katya Meridor, Tom Macleod, Andrew Scarsbrook, Kulveer Mankia, Edward Vital, Andrew Barr, Colin Pease, Helena Marzo‐Ortega, Sarah L. Mackie, Dennis McGonagle   +12 more
wiley   +1 more source

A Case of Sixth Cranial Nerve Palsy and Suspected Giant Cell Arteritis [PDF]

, 2017
Sudden onset of horizontal diplopia in an elderly patient can be due to giant cell arteritis. Although the patient reported was a vasculopath, a concurrent headache, mild reduction in visual acuity, scalp tenderness and raised inflammatory markers lead ...
D'Ath, P., Wilson, C. M.
core  

Unilateral multifocal choroidal ischemia revealing a giant cell arteritis: a case report

The Pan African Medical Journal, 2014
Temporal arteritis is a subacute systemic panarteritis with predilection over cranial arteries. Anterior ischemic optic neuropathy with or without the typical sectoral choroidal ischemia is the most common complication.
Zouheir Hafidi, Hanan Handor, Hamid Elmoussaif, Mina Laghmari, Abdelouahed Karmane, Samira Tachfouti, Rajae Daoudi   +6 more
doaj   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

True aneurysm of the peripheral pulmonary artery due to necrotizing giant cell arteritis [PDF]

, 2017
Pulmonary artery aneurysm in adults is a rare diagnosis. Most cases described in the literature are either associated with congenital heart disease or pulmonal arterial hypertension, respectively, or are not true aneurysms but rather pseudoaneurysms ...
Gebhart, Florin T.F., Kocher, Gregor J., Schmid, Ralph A., Steireif, Sven C.   +3 more
core  

Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis [PDF]

, 2017
Background Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study’s objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific ...
A Brack, AG Singh, AN Ezeonyeji, B Mari, C Ponte, Christian D. Mallen, CT Pease, CW Fry, D Schmidt, DB Hellmann, DM Nuenninghoff, E Kelkel, E Liozon, E Nordborg, E Smit De, E Wallace, F Bella Cueto, G Myklebust, G Nesher, GD Desmet, GG Hunder, H Petri, H Thulesius, Hoda Ranjbar, J Pattenden, James A. Prior, JC Robson, Jennifer Liddle, JH Smith, JM Gaspoz, John Belcher, K Barraclough, K Raza, KT Calamia, L Smeeth, LK Smith, M Czihal, MA Gonzalez-Gay, MA Gonzalez-Gay, MA Gonzalez-Gay, MA Gonzalez-Gay, MA Gonzalez-Gay, MJ Lopez-Diaz, ND Karanjia, P Duhaut, P Patil, P Patil, PD Aiello, RD Riley, S Kennedy, S Prieto-Gonzalez, Sarah L. Mackie, SE Scott, SL Mackie, SP Hozo, SS Hayreh, T Loddenkemper, TA Furukawa, Toby Helliwell, Z Hu   +59 more
core   +2 more sources

Clinical perspectives and comparisons between immunoglobulin G4‐related disease and antineutrophil cytoplasmic antibody‐associated vasculitis

Rheumatology &Autoimmunity, EarlyView.
Clinical perspectives and comparisons between immunoglobulin G4‐related disease and antineutrophil cytoplasmic antibody‐associated vasculitis. Abstract Both immunoglobulin (Ig) G4‐related disease (IgG4‐RD) and antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) are systemic disorders that affect a wide range of organs.
Wenhuan Zeng, Mingxin Bai, Yanying Liu
wiley   +1 more source