Results 81 to 90 of about 104,517 (284)

Giant Cell Arteritis: A Diagnostic Challenge in an Older Adult [PDF]

Geriatrics, Gerontology and Aging
Giant cell arteritis is a large-vessel vasculitis usually seen in older adults. The inflammatory process results in systemic, ophthalmic, and neurological lesions. It is difficult to diagnose in older adults and may present as a medical emergency.
Jorge Luiz de Carvalho Mello, Raul Sakuma Narita, Frederico Palumbo Araújo, Diba Maria Sebba Tosta de Souza, Vitor Angelo Carluccio Galhardo   +4 more
doaj   +1 more source

Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV‐154 in Adults With Glucocorticoid‐Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double‐Blind, Placebo‐Controlled Trial

Arthritis &Rheumatology, Volume 77, Issue 8, Page 1041-1051, August 2025.
Objective An unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.
Robert F. Spiera, Valerie Devauchelle‐Pensec, Claire E. Owen, Federico Díaz‐González, Tsutomu Takeuchi, Edit Drescher, Jaclyn Anderson, Dilek Arikan, Ronilda D'Cunha, Julie Parmentier, Denise T. Kruzikas, Weihan Zhao, Yang Yang, Karen Stellpflug, Frank Buttgereit   +14 more
wiley   +1 more source

Recent advances in the diagnosis and management of giant cell arteritis.

Current Opinion in Rheumatology, 2020
PURPOSE OF REVIEW Giant cell arteritis (GCA) has classically been diagnosed by temporal artery biopsy and treated with high-dose, long-term glucocorticoid therapy.
Naomi Serling-Boyd, J. Stone
semanticscholar   +1 more source

Diffuse large B cell lymphoma involving Meckel’s cave masquerading as biopsy-negative giant cell arteritis: a case report

Journal of Medical Case Reports, 2020
Background Given the absence of consensus diagnostic criteria for giant cell arteritis, clinicians may encounter difficulty with identification of new-onset headache in patients older than age 50 years presenting with visual changes and elevated ...
Matthew J. Samec, Andres G. Madrigal, Charlotte H. Rydberg, Matthew J. Koster   +3 more
doaj   +1 more source

Acute Stroke due to Vertebral Artery Dissection in Giant Cell Arteritis

Case Reports in Rheumatology, 2021
The diagnosis of giant cell arteritis (GCA) when presenting with atypical features such as stroke is very challenging. Only 0.17% of first-ever strokes are caused by GCA, a life-threatening condition when left untreated. Very few cases have been reported
Marlene Marte Furment, Sandra Antigua Jimenez, Sangeetha Pabolu   +2 more
doaj   +1 more source

Expert Perspective: Hematologic Malignancies and Vasculitis

Arthritis &Rheumatology, EarlyView.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source

A Giant Pulmonary Artery Aneurysm in a Young Male With Eisenmenger Syndrome

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT This case highlights a giant pulmonary artery aneurysm with a diameter of 107.7 mm, which is so far one of the most massive pulmonary aneurysms detected in a young person. Management may be extremely challenging in a resource‐poor setting where surgical interventions are not readily available.
Collins Kokuro, Prince Yaw Boahene, Solomon Gyabaah, Kwasi Ankomah, Emmanuel Acheamfour Akowuah, Lambert Tetteh Appiah, Bernard Cudjoe Nkum   +6 more
wiley   +1 more source

Giant Cell Arteritis

Неотложная медицинская помощь
Giant cell arteritis is a disease characterized by granulomatous inflammation of large and medium-sized arteries. The aorta and its large branches are most susceptible to pathological changes in this arteritis. The course of giant cell arteritis is often
E. V. Shevchenko, A. M. Izmailova, E. A. Kovaleva, G. R. Ramazanov   +3 more
doaj   +1 more source

Model‐Informed Drug Development‐Based Bridging from Subcutaneous to Intravenous Secukinumab Dosing: Approval in Psoriatic Arthritis and Axial Spondyloarthritis

Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 480-488, August 2025.
The objective of this modeling and simulation analysis was to determine an intravenous (IV) secukinumab dosing regimen with steady‐state exposure within the ranges of the approved subcutaneous (SC) regimens (300 and 150 mg every 4 weeks [q4w]) and to predict the efficacy and safety of this IV regimen for patients with psoriatic arthritis (PsA) or axial
Thomas Dumortier, Guillermo Valenzuela, Melvin Churchill, Jelena Mijatovic, Gerard Bruin, Luminita Pricop, Hanno Richards, Didier Renard, Atul Singhal, Anshu Marathe   +9 more
wiley   +1 more source

Giant cell arteritis as a cause of fever of unclear genesis in the elderly

Терапевтический архив, 2014
The paper describes a case of giant cell arteritis whose leading clinical sign is long-term fever. It discusses current approaches to diagnosing giant cell arteritis.
S V Guliaev, A D Meshkov, P I Novikov, S V Moiseev, V V Fomin   +4 more
doaj