Results 81 to 90 of about 177,876 (307)

Indication‐Specific Dosing and Dose‐Evaluation Strategies in New Indications for Non‐Oncology Monoclonal Antibodies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Compared to traditional small molecule drugs, monoclonal antibodies (mAbs) often display more complex pharmacokinetic (PK) and pharmacodynamic (PD) properties that may be impacted by disease‐specific factors. For mAbs in non‐oncology indications, where the same drug might be used for conditions involving different organ systems and/or having ...
Sherouk M. Tawfik, Fei Tang
wiley   +1 more source

Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis [PDF]

, 2017
Background Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study’s objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific ...
A Brack, AG Singh, AN Ezeonyeji, B Mari, C Ponte, Christian D. Mallen, CT Pease, CW Fry, D Schmidt, DB Hellmann, DM Nuenninghoff, E Kelkel, E Liozon, E Nordborg, E Smit De, E Wallace, F Bella Cueto, G Myklebust, G Nesher, GD Desmet, GG Hunder, H Petri, H Thulesius, Hoda Ranjbar, J Pattenden, James A. Prior, JC Robson, Jennifer Liddle, JH Smith, JM Gaspoz, John Belcher, K Barraclough, K Raza, KT Calamia, L Smeeth, LK Smith, M Czihal, MA Gonzalez-Gay, MA Gonzalez-Gay, MA Gonzalez-Gay, MA Gonzalez-Gay, MA Gonzalez-Gay, MJ Lopez-Diaz, ND Karanjia, P Duhaut, P Patil, P Patil, PD Aiello, RD Riley, S Kennedy, S Prieto-Gonzalez, Sarah L. Mackie, SE Scott, SL Mackie, SP Hozo, SS Hayreh, T Loddenkemper, TA Furukawa, Toby Helliwell, Z Hu   +59 more
core   +2 more sources

Giant oscillator strength in the band-edge light absorption of zincblende, chalcopyrite and kesterite solar cell materials [PDF]

Phys. Rev. Materials 4, 035402 (2020), 2019
In semiconducting solar-cell absorbers, high absorption coefficient (alpha) near the band-edge region is critical to maximize the photocurrent generation and collection. Nevertheless, despite the importance of the band-edge absorption characteristics, the quantitative analysis of the band-edge optical transitions has not been performed.
arxiv   +1 more source

Giant cell arteritis causing mesenteric ischemia without cranial manifestations: Report of an unusual case

Indian Journal of Pathology and Microbiology
Giant cell arteritis is a medium to large vessel vasculitis involving most commonly temporal arteries, vertebral and ophthalmic arteries. Giant cell arteritis causing mesenteric ischemia is not so frequent, more so if it occurs without cranial ...
Pritika Kushwaha, Meeta Singh, Priyanka Bellichuki, Rajdeep Singh   +3 more
doaj   +1 more source

Scalp Necrosis as a Late Sign of Giant-Cell Arteritis

Case Reports in Immunology, 2013
Retinal infarction and scalp necrosis are described as unusual but devastating complications of giant-cell arteritis. We report a patient with this rare complication and emphasize the importance of timely diagnosis and treatment of giant-cell arteritis.
Mohammad Alimohammadi, Ann Knight
doaj   +1 more source

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

Treatment of Giant Cell Arteritis and Takayasu Arteritis—Current and Future

Current Rheumatology Reports, 2020
Guidelines for the management of large vessel vasculitides have been recently updated by several scientific societies. We have evaluated the current recommendations for treatment of giant cell arteritis (GCA) and Takayasu arteritis (TA) and addressed ...
Bernhard Hellmich, A. Águeda, Sara Monti, R. Luqmani   +3 more
semanticscholar   +1 more source

True aneurysm of the peripheral pulmonary artery due to necrotizing giant cell arteritis [PDF]

, 2017
Pulmonary artery aneurysm in adults is a rare diagnosis. Most cases described in the literature are either associated with congenital heart disease or pulmonal arterial hypertension, respectively, or are not true aneurysms but rather pseudoaneurysms ...
Gebhart, Florin T.F., Kocher, Gregor J., Schmid, Ralph A., Steireif, Sven C.   +3 more
core  

Takayasu arteritis in childhood: retrospective experience from a tertiary referral centre in the United Kingdom. [PDF]

, 2015
Takayasu arteritis (TA) is an idiopathic large-vessel vasculitis affecting the aorta and its major branches. Although the disease rarely affects children, it does occur, even in infants.
Al-Obaidi, M, Brogan, PA, Dolezalova, P, Eleftheriou, D, McMahon, AM, Varnier, G   +5 more
core   +1 more source

Structure and Evolution of Giant Cells in Global Models of Solar Convection [PDF]

, 2007
The global scales of solar convection are studied through three-dimensional simulations of compressible convection carried out in spherical shells of rotating fluid which extend from the base of the convection zone to within 15 Mm of the photosphere.
arxiv   +1 more source