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Giant Cell Tumor of Bone

Surgical Pathology Clinics, 2012
This article provides an overview of giant cell tumor, including the typical clinical, radiographic, and pathologic findings, as well as some unusual features, such as multifocality and metastases. The article addresses recent advances in the molecular biology of giant cell tumor, particularly receptor activator of nuclear factor kappa B (RANK)-ligand ...
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Multicentric giant-cell tumor of bone

The Journal of Bone & Joint Surgery, 1977
The presence of more than one distinct giant-cell tumor in the same patient is rare; seven cases have been reported in the literature. The present series involves eleven patients with thirty-five individual tumors. Multifocal giant-cell tumors may pose a diagnostic problem.
F H, Sim, D C, Dahlin, J W, Beabout
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Giant Cell Tumors of the Sphenoid Bone

Neurosurgery, 1992
Giant cell tumors of the sphenoid are rare; there are 36 previously reported cases. We report two cases of these tumors in women in their thirties, both associated with pregnancy. In the first patient, the tumor was removed via a transnasal transsphenoidal approach. In the second patient, a Le Fort maxillotomy was required.
L D, Watkins   +4 more
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Giant Cell–Containing Tumors of Bone

Surgical Pathology Clinics, 2017
Giant cell-containing tumors of bone are characterized morphologically by the presence of numerous osteoclastic giant cells. Correlation of clinical, radiologic, and laboratory findings is required for accurate histopathologic diagnosis and treatment of a giant cell-containing tumor of bone.
Zsolt Orosz, Nicholas A. Athanasou
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Giant Cell Tumor of the Sphenoid Bone

Journal of Computer Assisted Tomography, 1983
A case of giant cell tumor of the sphenoid bone is reported, the first case in which a computed tomogram is available. The radiologic features of the neoplasm resembled both pituitary adenoma and parasellar meningioma, but with more bone destruction.
R F, Carmody, D J, Rickles, S F, Johnson
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Giant-cell tumors of the bones of the hand

The Journal of Hand Surgery, 1980
Twenty-eight giant-cell tumors of the bones of the hands of 21 patients were reviewed. There were 14 lesions in the phalanges, 12 in the metacarpals, and two in the carpal bones. Giant-cell tumor of bones develop at a younger age, have a shorter duration of symptoms, and recur more rapidly when they occur in the hand than when they occur in other ...
R M, Averill, R J, Smith, C J, Campbell
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The Study of Giant Cell Tumors in Bone

Orthopedics, 1989
ABSTRACT: Twelve samples of giant cell tumor of bone were incubated in the authors' laboratory. The activity of the cells was documented by means of time lapse cinemicrography. The multinuclear giant cells (MGCs) with undegenerating nuclei migrating from the expiants had active ameboid movement and continuously changed their shapes.
Q Y, Fan, Y P, Lu
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Multicentric Giant Cell Tumor of Bone

Clinical Orthopaedics and Related Research, 1996
Giant cell tumor of bone accounts for 4% to 5% of primary bone tumors in the United States. Multicentric giant cell tumors occur in < 1% of all patients with giant cell tumors, and only 43 patients with multicentric giant cell tumor have been reported on in the literature.
C A, Cummins   +2 more
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Giant cell tumor of bone

Human Pathology, 1982
E, Eisenberg, D J, Krutchkoff
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Giant-Cell Tumor of Bone

Clinical Orthopaedics and Related Research, 1980
The history of giant-cell tumor of bone includes important contributions by a group of scientists as distinguished as Lebert, Paget, Nélaton, Robin, Gross, Bloodgood, Ewing, and Jaffe. Various concepts of the origin and role of the osteoclast-like giant cell constitute the basis for present understanding of pathogenesis and treatment of the tumor ...
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