Cancers, 2021 Simple Summary The 2020 World Health Organization classification of soft tissue and bone tumors classified the giant cell tumor of bone (GCTB) as an intermediate malignant tumor, with locally aggressive behavior and high recurrence rate.
A. Parmeggiani +3 more
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Can p63 serve as a biomarker for giant cell tumor of bone? A Moroccan experience
Diagnostic Pathology, 2012 Background Multinucleated giant cell-containing tumors and pseudotumors of bone represent a heterogeneous group of benign and malignant lesions. Differential diagnosis can be challenging, particularly in instances of limited sampling. The purpose of this
Hammas Nawal +6 more
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Oral giant cell tumor or giant cell granuloma: How to know?
Heliyon, 2023 Introduction: The distinction between giant cell tumors and giant cell granulomas is challenging, as both entities have overlapping diagnostic criteria, especially in oral locations.
E. Hoarau +6 more
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Giant Cell Tumor of Bone: Documented Progression over 4 Years from Its Origin at the Metaphysis to the Articular Surface. [PDF]
, 2016 The exact location of origin for giant cell tumors of bone (GCTB) remains controversial, as lesions are not routinely imaged early but rather late when the tumor is large and clinically symptomatic.
Burke, Colin +4 more
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Cellular and molecular mediators of bone metastatic lesions [PDF]
, 2018 Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia +3 more
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Chondroblastoma of the Clivus: Case Report and Review. [PDF]
, 2015 Background and Importance Chondroblastoma is a benign primary bone tumor that typically develops in the epiphyses of long bones. Chondroblastoma of the craniofacial skeleton is extremely rare, with most cases occurring in the squamosal portion of the ...
Ahmadpour, Arjang +5 more
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A preclinical model for the ATLL lymphoma subtype with insights into the role of microenvironment in HTLV-1-mediated lymphomagenesis [PDF]
, 2018 \uef7f View references (83) Adult T cell Leukemia/Lymphoma (ATLL) is a mature T cell malignancy associated with Human T cell Leukemia Virus type 1 (HTLV-1) infection.
Adriana Mattiolo +8 more
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Denosumab in Giant Cell Tumor of Bone: Current Status and Pitfalls
Frontiers in Oncology, 2020 Denosumab is a monoclonal antibody against RANK ligand for treatment of giant cell tumor of bone (GCTB). Clinical trials and case series have demonstrated that denosumab is relevant to beneficial tumor response and surgical down-staging in patients of ...
Hengyuan Li +5 more
semanticscholar +1 more source
Giant cell tumor of bone: Unusual features of a rare tumor
Rare Tumors, 2019 Giant cell tumor of bone is a benign tumor with an aggressive behavior. Its typical subarticular location and high recurrence risk can be associated with significant morbidity. Although benign, it can rarely metastasize especially to the lungs.
Ziyad M Mohaidat +4 more
doaj +1 more source
Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone
Cell Death and Disease, 2021 Giant cell tumor of bone (GCTB) is an aggressive osteolytic bone tumor characterized by the within-tumor presence of osteoclast-like multinucleated giant cells (MGCs), which are induced by the neoplastic stromal cells and lead to extensive bone ...
Yunfei He +19 more
semanticscholar +1 more source