Results 31 to 40 of about 20,238 (218)
From Mimivirus to Mirusvirus: The Quest for Hidden Giants
Viruses, 2023 Our perception of viruses has been drastically evolving since the inception of the field of virology over a century ago. In particular, the discovery of giant viruses from the Nucleocytoviricota phylum marked a pivotal moment.
Morgan Gaïa, Patrick Forterre
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Virome comparisons in wild-diseased and healthy captive giant pandas
Microbiome, 2017 Background The giant panda (Ailuropoda melanoleuca) is a vulnerable mammal herbivore living wild in central China. Viral infections have become a potential threat to the health of these endangered animals, but limited information related to these ...
Wen Zhang +20 more
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A Brief History of Giant Viruses’ Studies in Brazilian Biomes
Viruses, 2022 Almost two decades after the isolation of the first amoebal giant viruses, indubitably the discovery of these entities has deeply affected the current scientific knowledge on the virosphere. Much has been uncovered since then: viruses can now acknowledge
Paulo Victor M. Boratto +16 more
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TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
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Cryo-electron microscopy of the giant viruses
Microscopy, 2021 Abstract High-resolution study of the giant viruses presents one of the latest challenges in cryo-electron microscopy (EM) of viruses. Too small for light microscopy but too large for easy study at high resolution by EM, they range in size from ∼0.2 to 2 μm from high-symmetry icosahedral viruses, such as Paramecium burseria Chlorella ...
Raymond N, Burton-Smith +1 more
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Annual Review of Microbiology, 1999 ▪ Abstract Paramecium bursaria chlorella virus (PBCV-1) is the prototype of a family of large, icosahedral, plaque-forming, double-stranded–DNA-containing viruses that replicate in certain unicellular, eukaryotic chlorella-like green algae. DNA sequence analysis of its 330, 742-bp genome leads to the prediction that this phycodnavirus has 376 protein-
Van Etten, James L., Meints, Russel
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Giant Viruses Encode Actin-Related Proteins [PDF]
Molecular Biology and Evolution, 2022 Abstract The emergence of the eukaryotic cytoskeleton is a critical yet puzzling step of eukaryogenesis. Actin and actin-related proteins (ARPs) are ubiquitous components of this cytoskeleton. The gene repertoire of the Last Eukaryotic Common Ancestor (LECA) would have therefore harbored both actin and various ARPs.
da Cunha, Violette +5 more
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Ancestrality and Mosaicism of Giant Viruses Supporting the Definition of the Fourth TRUC of Microbes
Frontiers in Microbiology, 2018 Giant viruses of amoebae were discovered in 2003. Since then, their diversity has greatly expanded. They were suggested to form a fourth branch of life, collectively named ‘TRUC’ (for “Things Resisting Uncompleted Classifications”) alongside Bacteria ...
Philippe Colson +10 more
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Quantitative Infection Dynamics of Cafeteria Roenbergensis Virus
Viruses, 2018 The discovery of giant viruses in unicellular eukaryotic hosts has raised new questions on the nature of viral life. Although many steps in the infection cycle of giant viruses have been identified, the quantitative life history traits associated with ...
Bradford P. Taylor +3 more
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The Secret Life of Giant Viruses in the California Current
mSystems, 2021 In the last few decades, the virology field has experienced a revolution in knowledge related to viral richness, diversity, and distribution in the oceans.
Jônatas Santos Abrahão
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