Results 41 to 50 of about 20,238 (218)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Characteristics of virophages and giant viruses

Acta Biochimica Polonica, 2018
Five years after being discovered in 2003, some giant viruses were demonstrated to play a role of the hosts for virophages, their parasites, setting out a novel and yet unknown regulatory mechanism of the giant viruses presence in an aqueous. So far, 20 virophages have been registered and 13 of them have been described as a metagenomic material, which ...
Wiesław Deptuła, Agata Poniewierska-Baran, Paulina Czupryńska, Beata Tokarz-Deptuła   +3 more
openaire   +3 more sources

Editorial: Large and Giant DNA Viruses [PDF]

Frontiers in Microbiology, 2019
Since the seminal studies involving bacteriophages, the DNA viruses have fascinated the scientific community. DNA viruses were essential not only for the understanding of viral biological process, but also were a fundamental tool for the discovery and expanding knowledge related to cellular processes, such as transcription, translation, DNA repair ...
Jônatas Abrahão, Bernard La Scola, Bernard La Scola   +2 more
openaire   +3 more sources

Investigations into the Diversity and Distribution of tRNA and Phylogenetics of Translation Factors in Amoebozoa-Infecting Nucleocytoviricota

Viruses
Translation is a sine qua non process for life as we know it. Translation factors (TFs) and tRNAs are rare among viruses but are commonly found in giant viruses of the class Megaviricetes.
Thaís I. R. Moreira, João Victor R. P. Carvalho, Clécio A. C. Filho, Júlia W. Souza, Bruna L. de Azevedo, Jônatas S. Abrahão, Rodrigo A. L. Rodrigues   +6 more
doaj   +1 more source

Hidden diversity of soil giant viruses [PDF]

Nature Communications, 2018
Abstract Known giant virus diversity is currently skewed towards viruses isolated from aquatic environments and cultivated in the laboratory. Here, we employ cultivation-independent metagenomics and mini-metagenomics on soils from the Harvard Forest, leading to the discovery of 16 novel giant viruses, chiefly ...
Frederik Schulz, Lauren Alteio, Danielle Goudeau, Elizabeth M. Ryan, Feiqiao B. Yu, Rex R. Malmstrom, Jeffrey Blanchard, Tanja Woyke   +7 more
openaire   +5 more sources

Virus Genomes from Deep Sea Sediments Expand the Ocean Megavirome and Support Independent Origins of Viral Gigantism

mBio, 2019
The nucleocytoplasmic large DNA viruses (NCLDV) of eukaryotes (proposed order, “Megavirales”) include the families Poxviridae, Asfarviridae, Iridoviridae, Ascoviridae, Phycodnaviridae, Marseilleviridae, and Mimiviridae, as well as still unclassified ...
Disa Bäckström, Natalya Yutin, Steffen L. Jørgensen, Jennah Dharamshi, Felix Homa, Katarzyna Zaremba-Niedwiedzka, Anja Spang, Yuri I. Wolf, Eugene V. Koonin, Thijs J. G. Ettema   +9 more
doaj   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Virophages of Giant Viruses: An Update at Eleven [PDF]

Viruses, 2019
The last decade has been marked by two eminent discoveries that have changed our perception of the virology field: The discovery of giant viruses and a distinct new class of viral agents that parasitize their viral factories, the virophages. Coculture and metagenomics have actively contributed to the expansion of the virophage family by isolating ...
Mougari, Said, Sahmi-Bounsiar, Dehia, Levasseur, Anthony, Colson, Philippe, La Scola, Bernard   +4 more
openaire   +4 more sources

High-throughput isolation of giant viruses in liquid medium using automated flow cytometry and fluorescence staining.

Frontiers in Microbiology, 2016
The isolation of giant viruses using amoeba co-culture is tedious and fastidious. Recently, the procedure was successfully associated with a method that detects amoebal lysis on agar plates. However, the procedure remains time-consuming and is limited to
Jacques Yaacoub Bou Khalil, stephane eRobert, Dorine gaëlle Reteno, Julien eAndreani, Didier eRaoult, Didier eRaoult, Bernard eLa Scola, Bernard eLa Scola   +7 more
doaj   +1 more source

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

Advanced Materials, EarlyView.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase, Varsha C. Pujari, Akash V. Fulari, Sunil M. Patange, Sean Li, Danyang Wang, Sagar E. Shirsath   +6 more
wiley   +1 more source